血液透析对尿毒症患者血清中炎症及氧化应激指标的影响

目的：探讨尿毒症患者血液透析前后C反应蛋白（cRP）、白细胞介素-6（IL-6）、脂质过氧化物丙二醛（MDA）、同型半胱氨酸（Hcy）等指标的水平变化及相互之间的关系。方法：选取26例透析时间在3个月以上的尿毒症患者为血透组，24例健康者为对照组，分别抽血检查CRP、IL-6、MDA、Hcy。结果：尿毒症患者透析前CRP、IL-6、MDA、Hcy水平明显升高，与对照组相比差别显著；血液透析治疗前后上述指标均有明显改变，血清CRP水平较透前升高，IL-6、MDA、Hcy水平明显下降。结论：尿毒症患者体内炎症及氧化应激水平增高，血液透析能够提高终末期肾衰患者血清中CRP水平，同时血液透析能够清除一定的IL-6、MDA及Hcy。

Changes of Inflammatory and Oxidative Stress Factors in Patients with End Stage Renal Disease Following Hemodialysis

Objective：To evaluate the changes of C-reactive protein （CRP） .interleukin-6 （IL-6） ,malondialdehyde （MDA） and Hcy （Homocysteine） levels in patients with end-stage renal disease （ESRD） following hemodialysis. Methods..Twenty-six cases with hemodialysis duration over three months were selected and twenty-four healthy persons as the control group, respectively blood tests CRP,IL-6, MDA and Hcy. Results ：CRP ,IL-6,MDA and Hcy levels were significantly elevated in patients with ESRD in comparison with the control group. After hemodialysis, CRP levels increased while IL-6,MDA, Hcy levels decreased significantly. Conclusion： In ESRD patients, who have elevated inflam-matory and oxidative stress factors, hemodialysis can increase CRP level and lower IL-6 ,MDA and Hcy levels.