| 离体大鼠心脏心室内压力与心室容积相关性探讨 |
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| 引用本文： | 赵廷存,张秀玲.离体大鼠心脏心室内压力与心室容积相关性探讨[J].新乡医学院学报,1999,16(1):12-14. |
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| 作者姓名： | 赵廷存 张秀玲 |
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| 作者单位： | 新乡医学院病理生理教研室(赵廷存)，平顶山煤炭卫生学校(张秀玲)，北京医科大学病生教研室(徐海) |
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| 摘 要： | 目的探讨离体大鼠心脏心室内压力与心室容积相关性。方法在离体大鼠收缩心脏模型上，通过左心耳切口放入左心室内一弹性好、无张力的乳胶小球，逐渐向小球内注射生理盐水以扩张小球容积。观察左心室收缩内压（ＬＶＳＰ）、左心室舒张期末压（ＬＶＥＤＰ）、发展压力（ＤＰ＝ＬＶＳＰ－ＬＶＥＤＰ）、左心室内压最大上升速率（ＬＶｄｐ／ｄｔｍａｘ）与左心室容积的相关性。结果在正常收缩状态下（Ｃａ２＋＝２．５ｍｍｏｌ·Ｌ－１），ＬＶＳＰ、ＬＶＥＤＰ、ＤＰ、ＬＶｄｐ／ｄｔｍａｘ与左心室容积的相关系数依次为０．８９３１、０．９７９３、０．６５２４、０．８４２０。结论提示左心室内压力与容积呈较强的相关性。
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| 关 键 词： | 心肌收缩性 左心室 相关性 |
Study on the relativity of left ventricular pressure and volume in the isovolumic rat hearts |
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| ZHAO Ting-Cun,ZHANG Xiu-Ling,XU Hai.Study on the relativity of left ventricular pressure and volume in the isovolumic rat hearts[J].Journal of Xinxiang Medical College,1999,16(1):12-14. |
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| Authors: | ZHAO Ting-Cun ZHANG Xiu-Ling XU Hai |
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| Abstract: | Objective Study the relativity of left ventricular pressure and volume in the isovolumic rat hearts. Methods In the model of isovolumic perfused rat hearts,a water-filled lates ballon was put in.The left ventricular cavity through the cut of left atrium, and a tube connecting to the out flow tract of the cylinder to form a close system was filled with salt water. Salt water was infused into the latex ballon gradually in order to change the volume of left ventricular Cavity.Result The results suggested that at the normal contractive condition(Ca=2.5mmol/L)、 LVSP-Volume、 LVEDP- Volume LVdp/dtmax- Volume and DP -Volume relationships remain liner. The values of each regression were 0.8931、0.9793、0.6524、0.842 1 respectively.Conclusion It is conclued that the cardiac hemodynamics have a much correlation with the left ventricular volume in the model of isovolumic perfused rat hearts. |
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| Keywords: | cardiac contractility left ventriculus correlation |
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