男性冠心病患者性激素及白细胞性激素受体变化的意义

目的探讨性激素变化与冠心病的关系。方法用放射免疫法和放射配体结合法分别测定36例男性冠心病患者性激素及白细胞性激素受体水平。并与24例健康男性作对照。结果男性冠心病患者血清雌二醇（E2）和睾酮（T）的比率及白细胞雌激素受体（ER）明显增加（P＜0．05），血清睾酮（T）、高密度脂蛋白胆固醇（HDL－C），载脂蛋白AI（APO－AI）和白细胞雄激素受体（AR）显著下降，且血清睾酮与高密度脂蛋白胆固醇呈正相关（P＜0．05）。白细胞雌激素受体及雄激素受体的亲和力（Kd）无明显变化（P＞0．05）。结论ER增高及雄性激素生物效应低下是男性冠心病的致病因子之一。

Changes and significance of sex hormone and hormone receptors in leukocytes in the males with coronary heart disease

Objective To asses the relationship between sex hormone and coronary heart disease(CHD).Methods Sex hormone and sex hormone receptors in leukocytes were detected in male patients (n=36) with CHD. respectively by radioimmunoassay and radio - liganal - binding -assay. Resuts The ratio of serum eatrodial (E2) to testoaterone(T) and the estrogen receptors(ER) in leukocytes were remarkablely increased (P<0.05); The serum T. high - density lipoprotein cholestrol(HDL-C). APO-AI and androgen receptors (AR) in leukocytes were decreased significantly (P<0.05). The level of serum T was positively correlatedwith HDL- C. There were no changes in the affinity of sex hormone receptor (P>0.05). Conclusions The increase of ER and decrease of activity of testosterone was one of pathogenetic factors of male CHD.