| 吗啡依赖大鼠胰岛A细胞免疫组织化学研究 |
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| 引用本文： | 李艳萍 刘健. 吗啡依赖大鼠胰岛A细胞免疫组织化学研究[J]. 新乡医学院学报, 1999, 16(1): 10-11 |
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| 作者姓名： | 李艳萍 刘健 |
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| 作者单位： | 新乡医学院(李艳萍)，临沂医学专科学校(刘健)，北京医科大学(邱学才) |
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| 摘 要： | 目的研究吗啡依赖大鼠Ａ细胞的变化，为探讨吗啡对Ａ细胞分泌功能的影响提供形态学依据。方法用皮下注射吗啡建立吗啡依赖大鼠模型，用免疫组织化学和图象分析方法观察胰岛Ａ细胞的变化。结果吗啡依赖大鼠Ａ细胞免疫反应增强（Ｐ＜０．０１）。结论吗啡可引起胰岛Ａ细胞分泌胰高血糖素的功能增强。
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| 关 键 词： | 吗啡依赖；胰岛A细胞；免疫组织化学；大鼠 |
Immunohistochemical study of A-cell of pancreatic islets inmorphine dependent rats |
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| LI Yan-Ping,LIU-Jian,QIU Xue-Chai. Immunohistochemical study of A-cell of pancreatic islets inmorphine dependent rats[J]. Journal of Xinxiang Medical College, 1999, 16(1): 10-11 |
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| Authors: | LI Yan-Ping LIU-Jian QIU Xue-Chai |
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| Abstract: | Objective To observe changes of A-cell of pancreatic islets and to put forward the morphological evidence to further research on the effects of morphine on the secretion of A-cell of pancreatic islets.Method The morphine dependent model of big rat was made by subcutaneous injection administrating morphine and observed by immunohistochemical survey and image analysis.Results Immumoreaction increased in the A-cell of pancreatic islets of the morphine dependent of big rat.Conclusion The morphine can give rise to increase in the function of the glucagon secreted by the A-cell of pancreatic islets. |
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| Keywords: | morphine dependence A-cell of pancreatic islets immunohistorchonicai big rat |
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