食管癌综合治疗的临床疗效分析

目的探讨综合治疗食管癌的临床疗效并与单纯放疗进行比较。方法７２例初次治疗的食管癌患者随机分为综合治疗组和单纯放疗组。综合组所用化疗方案为顺铂（ＤＤＰ）、５－氟脲嘧啶（５－Ｆｕ），放疗前化疗２个周期，放疗后化疗１个周期。两组放疗方法和剂量相同，每次１．８～２．０ＧＹ，１ｗｋ５次，总量达ＤＴ６５Ｇｙ左右／６．５～７ｗｋ。结果综合组临床疗效ＣＲ４１．７％（１５／３６），ＰＲ４４．４％（１６／３６），有效率（ＣＲ＋ＰＲ）８６．１％（３１／３６）；单纯放疗组ＣＲ１３．９％（５／３６），ＰＲ４１．７％（１５／３６），ＣＲ＋ＰＲ５５．６％（２０／３６）。综合组ＣＲ及有效率均优于单纯放疗组（Ｐ＜０．０５）。结论综合治疗食管癌能提高临床疗效。

Clinical observation of esophagus carcinoma treated with combination therapy

Objective To evaluate the clinical results of esophagus carcinoma treated by combination therapy and compare it with that of the sole radiotherapy. Methods Seventy-two previously untreated patients with esophagus carcinoma were randomly divided into two groups: the group of combination therapy and the group of sole radiotherapy. The chemotherapy regimen was DDP5-Fu,with two cycles before radiotherapy and one cycle after radiotherapy. The method and dose of the two radiotherapy were the same,1.82.0GY per time,five times a week. The total dose was about 65GY/6.57wk. Results The response rate in the group of combination therapy was CR 41.7%,PR 44. 4%, CR PR 86.1% and that of sole radiotherapy was CR 13.9%;PR41.7%,CR PR 55.6%.The combination therapy's CR and effective rate were all better than that of the sole radiotherapy(P<0.05). ConclusionZCombination therapy can enhance the clinical effect of esophagus carcinoma.