降纤酶治疗急性脑梗死的对比研究

目的观察降纤酶治疗急性脑梗死的临床疗效。方法１８０例患者随机分治疗组９０例和对照组９０例。治疗组应用降纤酶每次１０Ｕ，每日１次静脉滴注，连用４ｄ。对照组应用低分子右旋糖酐每次５００ｍｌ，每日１次静脉滴注，连用１４ｄ。结果用χ２检验进行统计学分析。结果治疗组治愈２２例（２４．４％），显效４０例（４４．４％），总有效率９０％（８１／９０），对照组总有效率６４．４％（５８／９０）。两组总有效率有显著性差异（Ｐ＜０．０１）。治疗组在发病６ｈ内、２４ｈ内用药的总有效率分别为９３．８％、８７．９％，无显著差异（Ｐ＞０．０５）。结论早期应用降纤酶治疗急性脑梗死有显著疗效。

Comparative study of defibrase for acute cerebral infarction

Objective To observe the therapeutic effect of defibrase for acute cerebral infarction.Methods One hundred and eighty cases with acute cerebral infarction were randomly divided into two groups: 90 cases in the treatment group and 90 cases in the control group.The treatment group was treated with defibrase (10U·d -1 ),iv for 4d. The control group was treated with dextrn-40(500ml·d - 1),iv for 14d. The results were analyzed statistically with x 2 -test. Results In the treatment group,22 cases were cured (24.4%) and 40 cases were improved obviously (44.4%),the total effection rate was 90% (85/90).In the control group the total effection rate was 64.4% (58/90). There were extremely obvious difference between the two groups ( P <0.01). In the treatment group, the gross effection rate was 93.8% within 6h and 87.9% within 24h ( P >0.05). Conclusion The Defibrase for acute cerebral infarition in early stage is obviously effective.