Interferon-gamma production closely related to antibody production in lymphocyte cultures stimulated with mumps virus |
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| Authors: | T Nakayama S Unno T Urano M Osano K Sasaki S Makino |
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| Affiliation: | Department of Pediatrics, Keio University, School of Medicine, Japan. |
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| Abstract: | Enzyme-linked immunosorbent assay (ELISA) antibody to mumps virus and virus specific interferon (IFN)-gamma production were investigated in lymphocyte cultures stimulated with mumps virus before and after immunization with live mumps vaccine. Synthesis of immunoglobulin (Ig) M but not Ig G was enhanced after vaccination. Spontaneous production of mumps ELISA antibodies in lymphocyte culture increased after vaccination and substantially higher levels of antibodies were produced when lymphocytes were stimulated with mumps virus after vaccination. The production of mumps ELISA antibodies was closely related to IFN-gamma production (r = 0.326, p less than 0.01) but not to IFN-alpha production (r = 0.084, p greater than 0.05). |
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