| 加锡果宁抑制荷包牡丹碱在大鼠海马脑片CAl区诱发的痫样放电 |
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| 引用本文： | 李玉菎,杨世若,戴晓黎,常志青. 加锡果宁抑制荷包牡丹碱在大鼠海马脑片CAl区诱发的痫样放电[J]. 中国药理学与毒理学杂志, 1992, 0(3) |
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| 作者姓名： | 李玉菎 杨世若 戴晓黎 常志青 |
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| 作者单位： | 华西医科大学生理教研室，华西医科大学生理教研室，四川省卫生管理干部学院，河南省中医研究院 成都 610041，成都 610041 |
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| 基金项目： | 四川省科委应用基础研究专项基金 |
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| 摘 要： | 在大鼠离体海马脑片标本表面灌流荷包牡丹碱(10μmol·L~(-1)),单脉冲电刺激Schaffer侧支,激活CAl区锥体细胞,给出痫样放电,作者在这种痫样放电模型上研究了加锡果宁对该痫样放电的影响,结果表明,微量推注不同浓度的加锡果宁到脑片CAl区表面,对荷包牡丹碱诱发的CAl区锥体细胞痫样放电呈剂量依赖性抑制,提示加锡果宁可对抗荷包牡丹碱的致痫作用,并讨论了可能机理。
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| 关 键 词： | 加锡果宁 海马脑片 荷包牡丹碱 痫样放电 |
Inhibition of bicuculline-induced epileptiform activity by edulinine in rat hippocampal slices |
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| LIYu-Kun,YANGShi-Ruo,DAI Xiao-Li,CHANG Zhi-Qing. Inhibition of bicuculline-induced epileptiform activity by edulinine in rat hippocampal slices[J]. Chinese Journal of Pharmacology and Toxicology, 1992, 0(3) |
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| Authors: | LIYu-Kun YANGShi-Ruo DAI Xiao-Li CHANG Zhi-Qing |
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| Affiliation: | LIYu-Kun,YANGShi-Ruo,DAI Xiao-Li,CHANG Zhi-QingDepartment of Physiology,West China University of Medical Sciences,Chengdu 610041 |
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| Abstract: | The epileptiform activity of pyramidal cells in CA1 area in the rat hippocampal slices in vitro was produced by superfusion of the bicuculline and single shocks of Schaffer collaterals, and the effect of edulinine on the bicuculline-induced epileptiform activity was studied. The result shows that the constant-rate local application of edulinine at theconcentrations of 0.1, 1.0, 2.0 and 3.0 mmol·L-1 onto the surface of the slices dose-dependently inhibits the bicuculline-induced epileptiform activity. The possible mechanism involved was discussed. |
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| Keywords: | edulinine hippocampal slices bicuculline epileptiform activity |
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