CO2激光联合盐酸氨酮戊酸散光动疗法治疗尖锐湿疣的疗效观察

目的观察CO2激光联合外用盐酸氨酮戊酸散光动疗法（aminolevulinic acid hydrochloride for topical powderphotodynamictherapy,ALA-PDT）治疗尖锐湿疣的临床疗效与安全性。方法治疗组36例患者,经CO2激光术后联合ALA-PDT,1周治疗1次,连续治疗3周;对照组28例患者,经CO2激光术后,联合使用咪喹莫特乳膏涂抹患处,1周3次,连续使用8周。2组患者均在末次治疗后第1周进行疗效评价和不良反应观察,第4～8周观察复发率。结果末次治疗1周时,2组疣清除率均为100%,无统计学差异（P〉0.05）;2组均无全身不良反应,局部不良反应治疗组为13.89%,主要为红肿、疼痛、渗液,对照组为64.29%,主要为疼痛、糜烂、红肿、红斑等,具统计学差异（P〈0.05）。结论 CO2激光联合ALA-PDT治疗尖锐湿疣,清除速度快,疣体清除率高,复发率低,安全,耐受性好,无明显副作用,值得临床推广。

Clinical efficacy of the CO2 laser therapy combined aminolevlinic acid hydrochloride for topical powder photodynamictherapy to treat condyloma accuminatum

Objective To observe the clinical efficacy and safety of the CO2laser therapy combined aminollevlinic acid Hydrochloride for topical powder photodynamictherapy to treat condyloma accuminatum.Methods A total of 36 patients were studied in the treatment group,combined ALA-PDT after the CO2laser therapy,once a week for 3weeks.And 28 patients in the contrast group,combined imiquimod cream after the CO2laser therapy,three times a week for 8 weeks.We observe the efficacy and adverse reaction in the first week after the last treatment,and also the recurrence rate at 4to 8 weeks.Results The first week after the last treatment,the clearance was 100%,with no statistically significant difference in the 2groups（P0.05）.The recurrence in the treatment group was 5.56%,and that of the control group was 7.14%,with no statistically significant difference（P0.05）.There were no systemic adverse re-actions in the 2groups.Local reactions was 13.89%for the treatment group,including swollen,pain,and drainage,and 64.29%for the contol group,including pain,anabrosis,swollen,and erythema,it has significantly difference（P0.05）.Conclusion CO2laser therapy combined ALA-PDT for condyloma accuminatum is high clearance speed,and low recurrence rate.It is safe,tolerable,with no obvious side effects.