LACK OF ENDOGENOUS OPIOID INHIBITORY TONE ON LH SECRETION IN EARLY PUBERTY |
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| Authors: | F. FRAIOLI M. CAPPA A. FABBRI L. GNESSI C. MORETTI PATRIZIA BORRELLI A. ISIDORI |
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| Affiliation: | V Clinica Medica, Policlinico Umberto I∘, University of Rome, Ospedale Bambino Gesù, Department of Endocrinology, Rome, Chair of Andrology, University of Rome, Italy |
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| Abstract: | Thirteen normal children, seven males and six females, during early puberty (I-II according to Tanner), have been studied. Each subject was injected at weekly intervals and in random order with 100 micrograms of LHRH, 0.2 mg/kg of naloxone and 0.9% saline in single bolus. The gonadotrophin response was evaluated. The administration of naloxone failed to elevate LH levels in any of the subjects studied, even in those who showed a clear gonadotrophin response to LHRH. Unlike the response noted in adults, endogenous opiates do not appear to exert a tonic inhibitory influence on LH secretion during early puberty. |
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