人白细胞抗原与宫颈癌及癌前病变相关研究

目前大量的研究表明，高危型人类乳头瘤病毒（high—risk human papillomavirus，HPVhr）的感染与宫颈癌的发生密切相关，同时也发现了单纯的HPV感染不足以引起宫颈癌的发生，还需要其他分子事件的共同参与；宫颈癌的发生也是一个伴有细胞基因遗传改变的多步骤、多因素的过程，而且细胞内遗传因素的改变可能具有非常重要的意义。现在对于人向细胞抗原（HLA）基因多态性与宫颈癌及癌前病变的相关性研究成为热点之一。针对HLA的功能、在宫颈癌细胞上表达异常的机制、测定和分型的方法及与宫颈癌的治疗等几方面探讨HM与宫颈癌及癌前病变的相关性进展。

The Development of Study on Relationship Between HLA Alleles and Cervical Cancer and Its Precancerous Lemons

Previous numerous studies have strongly shown that certain high-risk HPV infection clearly plays an important role in the development of cervical carcinoma; however, several experimental studies have suggested that HPV infection alone is insufficient to initiate malignant transformation of the cervical epithelium because many more women are infected with HPV than develop cervical cancer. Thus other genetic events are likely to be critical in the pathogenesis of cervical cancer. At present, the relationship between gene polymorphism of HLA alleles and cervical cancer and its precancerous lesions becomes one of hot spots. This article gives an overview of the progress in several aspects such as function, expression mechanism, typing method et al.