沐舒坦联合纳洛酮治疗胎粪吸入综合征74例临床观察

目的观察沐舒坦、纳洛酮联合治疗胎粪吸入综合征的疗效。方法自2003年1月～2007年1月在我科就诊的胎粪吸入综合征74例，随机分为治疗组40例和对照组34例。两组均给予常规治疗，治疗组在常规治疗基础上加用沐舒坦、纳洛酮，其中沐舒坦每次7．5mg／kg，q6h1次；纳洛酮针首次负荷量0．1mg慨静推，1h后按0．01mg／（kg·h）的速度经微量输液泵持续静脉注射，每日总量不超过0．4mg／kg。结果在治疗结束时，治疗组显效27例（67．5％），有效11例（27．5％），总有效率为95．0％（38／40）；对照组显效15例（44．1％），有效10例（29．4％），总有效率为73．5％（25／34）。两组显效率比较差异有显著性意义（Х^2=4．09，P〈0．05），总有效率比较差异有非常显著性意义（Х^2=6．69，P〈0．01）。结论沐舒坦联合纳洛酮治疗胎粪吸入综合征疗效显著，值得临床进一步研究。

Evaluation for Effect of Mucosolvan in Combination with Naloxone on Meconium Aspiration Syndrome

Objective To evaluate the effect of mucosolvan in combination with naloxone on meconium aspiration syndrome(MAS). Methods Seventy-four patients with MAS in our department from January 2003 to January 2007,were divided randomly into control group(n=34) and treatment group(n=40). All patients were treated by conventional therapy,and treatment group were given combined with mucosolvan and naloxone,and mucosolvan(7.5mg/kg) was given every six hour;naloxone(0.1mg/kg) was injected into the blood- stream for the f...