睾酮与男性代谢综合征

男性血清睾酮水平与代谢综合征的发生、发展密切相关.低睾酮水平可能导致腹型肥胖、糖代谢异常、血脂紊乱及高血压,给予睾酮水平低下者睾酮替代治疗(TRT)能明显改善其相关代谢指标.同时,腹型肥胖、糖代谢异常也可通过抑制Leydig细胞功能、增加芳香化酶活性等引起睾酮水平下降.

Testosterone and metabolic syndrome in men

Testosterone levels in men are closely associated with the onset and development of metabolic syndrome. Low testosterone levels can lead to visceral obesity,abnormal glucose metabolism,lipid disorders and hypertension. Testosterone replacement therapy (TRT) can improve the features of metabolic syndrome in hypogonadal males significantly. Conversely, visceral obesity and abnormal glucose metabolism can cause a lower testosterone level through increasing the activity of aromatase, suppression of Leydig cell function and so on.