| API0134对凝血酶作用下血小板环核苷酸和胞浆游离钙离子浓度的影响 |
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| 引用本文： | 李树生,赵华月,郭志凌.API0134对凝血酶作用下血小板环核苷酸和胞浆游离钙离子浓度的影响[J].华中科技大学学报(医学版),1999,28(2). |
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| 作者姓名： | 李树生 赵华月 郭志凌 |
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| 作者单位： | 1. 同济医科大学附属同济医院,急诊科,武汉,430030
2. 同济医科大学附属同济医院,内科心血管,武汉,430030 |
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| 摘 要： | 为观察穿心莲有效成分（ＡＰＩ０１３４）对凝血酶作用下血小板活化的抑制作用，将家兔２４只随机分为ＡＰＩ０１３４（Ａ）组（ｎ＝９），噻氯匹定（Ｔ）组（ｎ＝８）和对照组（ｎ＝７），治疗１周，然后检测凝血酶作用下血小板内ｃＡＭＰ、ｃＧＭＰ和胞浆游离钙离子浓度，以及血小板超微结构。结果表明ｃＡＭＰ水平在Ａ、Ｔ两组显著高于Ｃ组（Ｐ＜０．０５），而胞浆游离钙离子浓度明显低于Ｃ组（Ｐ＜０．０１），超微结构表明Ａ组和Ｔ组血小板脱颗粒现象较Ｃ组明显减轻。在Ａ和Ｔ组之间各项参数均无统计学差异。结论：ＡＰＩ可抑制凝血酶诱导的血小板活化反应
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| 关 键 词： | API_(0134) 环磷酸腺苷 钙离子 凝血酶 血小板活化 噻氯匹定 |
Effects of API0134 on the Thrombin-induced Platelet Cyclic Nucleotide and Cytoplasmic Free Ca2+ |
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| Li Shusheng,Zhao Huayue,Guo Zhiling.Effects of API0134 on the Thrombin-induced Platelet Cyclic Nucleotide and Cytoplasmic Free Ca2+[J].Journal of Huazhong University of Science and Technology(Health Sciences),1999,28(2). |
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| Authors: | Li Shusheng Zhao Huayue Guo Zhiling |
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| Abstract: | In order to observe the inhibitory effect of Andrographis Paniculata Isolate 0134(API 0134 ,API) on the anti thrombin induced platelet activation, 24 domestic rabbits were randomly divided into API pretreated group ( n= 9), ticlopidine (T) pretreated group ( n= 8), and control (C) group ( n= 7). The rabbits received the treatment for 1 week. After induction with thrombin following parameters were measured: cAMP, cGMP and concentration of cytoplasmic free Ca 2 . Ultrastructural changes of platelets were also examined. cAMP level was markedly higher in API and T groups than in C group ( P <0.05), while the concentration of free Ca 2 in both API and T groups was markedly lower than in C group ( P <0.01). The ultrastructural changes of platelets showed the degranulation in API and T groups was much milder than in C group. API may inhibit thrombin induced activation of platelets. |
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| Keywords: | API 0134 cyclic nucleotide calcium ion thrombin platelet activating ticlopidine |
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