国产药三联治疗艾滋病的疗效

目的　观察国产去羟肌苷散、司他夫定和奈韦拉平 (三药 )联合治疗艾滋病患者的初步疗效和早期不良反应。方法　艾滋病患者 8例 ,给予三药联合治疗 ,随访 9个月。监测患者的治疗前和治疗 1、3、6、9个月时的血浆病毒载量及CD4 T淋巴细胞计数 ,并评价药物不良反应。结果　经过治疗患者血浆中HIVRNA含量均明显降低 ,CD4 T淋巴细胞数量增加。早期的药物不良反应较少。结论　 8例患者的 9个月随访显示 ,国产三药联合治疗在早期就能有效抑制艾滋病病毒的复制 ,机体免疫功能也有改善 ,具有良好的耐受性

Clinical Efficacy of Tri-therapy with Domestic Drugs in AIDS

Purpose To observe the efficacy and side effects of Tri-therapy with domentic drugs in acquired immunodeficiency syndrome (AIDS). Methods Totally 8 AIDS patients were treated with didanosine,stavudine and nevirapine combined therapy.All cases were followed up for 9 months.The plasma HIV-1 RNA lever and CD4 T cell count of the patients were measured at the beginning of treatment and the end of the first,third,sixth,ninth month.Adverse events were monitored in all the 8 patients. Results The lever of plasma HIV-1 RNA was significantly decreased (P<0.001), and CD4 cell count was significantly increased (P<0.05) in each of the 8 patients.The adverse effects of the three kinds of drugs were mild during the first 9-months. Conclusions During the first 9-months,8 patients who received didanosine, stavudine and nevirapine combined therapy were well tolerated,and they all got rapid immunological and antiviral response.