Anti‐epidermal growth factor receptor therapy concurrently with induction chemotherapy in locoregionally advanced nasopharyngeal carcinoma |
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Authors: | Hao Peng Ling‐Long Tang Xu Liu Lei Chen Wen‐Fei Li Yan‐Ping Mao Yuan Zhang Li‐Zhi Liu Li Tian Ying Guo Ying Sun Jun Ma |
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Institution: | 1. State Key Laboratory of Oncology in South China, Department of Radiation Oncology, Sun Yat‐sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China;2. State Key Laboratory of Oncology in South China, Imaging Diagnosis and Interventional Center, Sun Yat‐sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China;3. State Key Laboratory of Oncology in South China, Department of Clinical Trials Center, Sun Yat‐sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China |
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Abstract: | Little is known about the efficacy and toxicity of anti‐epidermal growth factor receptor therapy concurrently with induction chemotherapy (IC) in locoregionally advanced nasopharyngeal carcinoma (LA‐NPC). The present study aimed to address this question. We identified 2848 patients with newly diagnosed LA‐NPC receiving IC between January 2012 and May 2015. The propensity score matching (PSM) method was used to balance various factors and to match patients. Survival outcomes and toxicities between different groups were compared. In total, 596 patients were selected at a 1:3 ratio, with 149 in the IC + CTX/NTZ group and 447 in the IC alone group. The 3‐year disease‐free survival, overall survival, distant metastasis‐free survival and locoregional relapse‐free survival rates for IC + CTX/NTZ vs IC alone were 84.3% vs 75.2% (P = .059), 94.0% vs 87.9% (P = .053), 88.0% vs 84.9% (P = .412) and 93.3% vs 88.2% (P = .242). Multivariate analysis established a treatment group (IC vs IC + CTX/NTZ) as a prognostic predictor for DFS (hazard ratio HR], 1.497; 95% confidence interval CI], 1.016‐2.206; P = .041) and OS (HR, 1.984; 95%, CI, 1.023‐3.848; P = .043). Grade 3‐4 skin reaction (15.4% vs 0.4%, P < .001) and mucositis (10.1% vs 2.7%, P < .001) were more common in the IC + CTX/NTZ group than that in the IC alone group. Our findings suggested that CTX/NTZ in combination with IC may be a more effective and promising strategy for patients with LA‐NPC treated with intensity‐modulated radiotherapy. |
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Keywords: | cetuximab induction chemotherapy intensity‐modulated radiotherapy nasopharyngeal carcinoma nimotuzumab |
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