| 交链孢酚单甲醚在大鼠小鼠体内的分布 |
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| 引用本文： | 石智勇,刘桂亭,钱玉珍,董子明,苗健,裴留成,甄应中. 交链孢酚单甲醚在大鼠小鼠体内的分布[J]. 郑州大学学报(医学版), 1990, 0(2) |
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| 作者姓名： | 石智勇 刘桂亭 钱玉珍 董子明 苗健 裴留成 甄应中 |
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| 作者单位： | 河南医科大学病理生理学教研室(石智勇，刘桂亭，钱玉珍，董子明)，河南医科大学食管癌研究室(苗健，裴留成)，河南医科大学食管癌研究室(甄应中) |
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| 摘 要： | 对食管癌高发区粮食中分离的互隔交链孢霉的毒素交链孢酚单甲醚(AME)在大鼠、小鼠体内的分布进行研究。给动物腹腔内注射氚标记的交链孢酚单甲醚(~3H-AME),然后在不同时间测各脏器的放射性。结果表明:在所测9个脏器中,2h肝脏含量最高,食管下段在大小鼠分别居第四和第三。但大小鼠分别在72、24h则以食管下段最高,说明AME及其代谢物在此清除较慢,即对其有较高的亲和力。
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| 关 键 词： | 食管癌 病因学 交链孢霉属 大鼠 小鼠 分布 |
The distribution of alternariol monomethyl ether in rats and mice |
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| Shi Zhiyong,Liu Guiting,Qian Yuzhen,Dong Ziming,Miao Jian,Pei Liucheng,Zhen Yingzhong. The distribution of alternariol monomethyl ether in rats and mice[J]. Journal of Zhengzhou University: Med Sci, 1990, 0(2) |
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| Authors: | Shi Zhiyong Liu Guiting Qian Yuzhen Dong Ziming Miao Jian Pei Liucheng Zhen Yingzhong |
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| Affiliation: | Shi Zhiyong;Liu Guiting;Qian Yuzhen;Dong Ziming;Miao Jian;Pei Liucheng;Zhen Yingzhong Department of Pathophysiology Department of Esophageal Cancer Research |
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| Abstract: | The distribution of alternariol monomethyl ether (AME) in rats and micewas studied. The AME was produced by Alternaria alternata isolated from thegrain in an area of high incidence of esophageal cancer. The animals were given ~3H-AME, and the radioactivity in various organs was measured at varioustime intervals. The results demonstrated that the radioactivity in the liverwas the highest of the nine organs examined 2 hr after dosing; the lowerpart of the esophagus was the fourth and the third in rats and mice respecti-vely. But the radioactivity in the lower part of the esophagus was the highestin rats and mice 72 hr and 24 hr after administration of ~3H-AME respectively The results suggest that the elimination of AME and its metabolitesmay be the slowest in the lower part of the esophagus, ie, they possess thehigbest affinity to it. |
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| Keywords: | esophageal cancer etiology alternaria rats mice distribution |
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