| 高效液相色谱法测定愈肝片中维生素C的含量 |
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| 引用本文： | 常红,高红梅,赵源慧,鞠蒙蒙,吴伟. 高效液相色谱法测定愈肝片中维生素C的含量[J]. 中国医药指南, 2012, 0(36): 410-410 |
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| 作者姓名： | 常红 高红梅 赵源慧 鞠蒙蒙 吴伟 |
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| 作者单位： | 吉林修正药业新药开发有限公司 |
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| 摘 要： | 目的建立愈肝片中测定维生素C的高效液相色谱法。方法采用Agilent ZORBAX SB-Aq C18柱(250mm×4.6mm,5μm),柱温为25℃,以乙腈-0.1%的辛烷磺酸钠的0.1%的草酸溶液(2∶98)为流动相,流速1.0mL/min,检测波长为249nm。结果维生素C的线性范围为0.103～0.414μg(r=1.0000),平均回收率为99.3%,RSD为1.3%。结论本方法简便,快速,准确,重现性好,可用于本品的质量控制。
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| 关 键 词： | 愈肝片 维生素C 高效液相色谱法 含量测定 |
Determination of VitaminC in Yugan Tablets by HPLC |
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| CHANG Hong,GAO Hong-mei,ZHAO Yuan-hui,JU Meng-meng,WU Wei. Determination of VitaminC in Yugan Tablets by HPLC[J]. Guide of China Medicine, 2012, 0(36): 410-410 |
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| Authors: | CHANG Hong GAO Hong-mei ZHAO Yuan-hui JU Meng-meng WU Wei |
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| Affiliation: | (Jilin Xiuzheng Medicine Company Drug Development Co.,Ltd,Changchun130012,China) |
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| Abstract: | Objective To establish a method for the determination of Vitamin C in Yugan Tablets.Methods Agilent ZORBAX SB-Aq C18 column（4.6mm× 250mm,5μm） was used as chromatographic column,the acetonitrile-0.1% octane sulfonate,0.1% oxalic acid solution（2∶98） was used as mobile phase,the flow rate was 1.0mL/min.the detection wavelength was set at 249nm.Results The standard curves was linear in the rang of 0.103～0.414μg（r=-1.0000）,the average recovery was 99.3%with a RSD of 1.3%.Conclusion The method is simple.accurate and reproducible,and is suitable for quality control of this tablets. |
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| Keywords: | Yugan Tablets HPLC Vitamin C Content determination |
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