草酸铂加CF／5-FU48小时持续静脉滴注双周疗法治疗晚期胃癌83例疗效分析

目的：观察草酸铂（L-OHP）与CF／5-Fu48小时持续静脉滴注双周疗法治疗晚期胃癌疗效及不良反应。方法：经病理证实的83例晚期胃癌患者随机分为治疗组和对照组。治疗方案：治疗组用L-OHP加CF／5-FU：对照组用VP16加CF／5-FU，两组均2周为1周期。结果：经过2个周期化疗，治疗组有效率（CR＋PR）57．5％比对照组有效率34．9％高，两组比较差异有统计学意义（X^2=4.2702，P=0．0388）。治疗中无疾病进展及治疗相关死亡。胃肠道反应及骨髓抑制均为轻中度。无显著性差异。神经毒性治疗组明显低于对照组，两组差异有统计学意义（P〈0．01）。结论：L-OHP加CF／5-FU48小时持续静脉滴注双周疗法治疗晚期胃癌疗效高，不良反应轻，有希望成为最有效的治疗方案。

Clinical study of the curative effect of oxaliplatin plus CF/5-FU in advanced gastric cancer by biweekly therapy of 48-hour continuous intravenous infusion

Objective:To observe the anti-tumor effect and safety of oxaliplatin combined with CF/5-FU in the treatment of advanced gastric cancer by biweekly therapy of 48-hour continuous intravenous infusion.Methods:83 patients with advanced gastric cancer were randomly divided into treatment group and control group.Treatment group was treated with oxaliplatin plus CF/5-FU added into the chemotherapy pump by 48-hour continuous intravenous infusion,while Control group was treated with VP16 plus CF/5-FU in the same method as treatment group,a cycle was two weeks.All enrolled patients received two cycles of treatment.Results:The effective rate was 57.5% in the treatment group and 34.9% in the control group,with a significant difference between them(x2=4.2902,P=0.0388).There was no significant difference in bone marrow suppression,nausea and vomiting between two groups.The rate of peripheral neurilemmitis response had significant difference between two groups(P<0.001).Conclusion:Oxaliplatin plus CF/5-FU by biweekly therapy of 48-hour continuous infusion is very effective for the treatment of advanced gastric cancer with mild toxicity,which can be practiced safety.