谷红注射液联合盐酸法舒地尔治疗缺血性脑梗死的临床研究

目的探究谷红注射液联合盐酸法舒地尔注射液治疗缺血性脑梗死的临床疗效。方法选取遵义医学院附属医院2013年5月—2015年5月收治的缺血性脑梗死患者78例,根据治疗方案的不同分为对照组和治疗组,每组各39例。所有患者均给予降低颅内压、营养神经、调节血脂等基础治疗。对照组静脉滴注盐酸法舒地尔注射液,60 mg加入250 m L生理盐水中,1次/d。治疗组在对照组基础上静脉滴注谷红注射液,20 m L加入150 m L生理盐水中,1次/d。两组患者治疗14 d。观察两组的临床疗效,比较两组治疗前后血液流变学、内皮素-1(ET-1)和神经功能缺损量表(NIHSS)评分的变化。结果治疗后,对照组和治疗组总有效率分别为79.49%、87.18%,两组比较差异有统计学意义(P0.05)。治疗后,两组患者红细胞沉降率(ESR)、血细胞比容(HCT)、纤维蛋白原(FIB)、红细胞聚集指数(RF)、全血高切黏度(HBV)均较治疗前下降,同组治疗前后差异具有统计学意义(P0.05);治疗组ESR、HCT、RF以及HBV的改善程度优于对照组,两组比较差异具有统计学意义(P0.05)。治疗后,两组患者NIHSS评分及ET-1均较治疗前显著下降,同组治疗前后差异具有统计学意义(P0.05);且治疗组这些观察指标的改善程度优于对照组,两组比较差异具有统计学意义(P0.05)。结论谷红注射液联合盐酸法舒地尔注射液治疗缺血性脑梗死具有较好的临床效果,能够明显改善患者的血液流变学状态,并能显著降低ET-1,具有一定的临床推广应用价值。

Clinical observation of Guhong Injection combined with fasudil hydrochloride in treatment of ischemic cerebral infarction

Objective To explore the clinical effect of Guhong Injection combined with Fasudil Hydrochloride Injection in treatment of ischemic cerebral infarction. Methods Patients (78 patients) with ischemic cerebral infarction in Affiliated Hospital of Zunyi Medical College from May 2013 to May 2015 were divided into control and treatment groups according to the different treatment plans, and each group had 39 cases. All patients were given conventional basic treatment with reducing intracranial pressure, trophic nerve, and lipid regulating. Patients in the control group were iv administered with Fasudil Hydrochloride Injection, 60 mg added into 250 mL normal saline, once daily. Patients in the treatment group were iv administered with Guhong Injection, 20 mL added into 150 mL normal saline, once daily. The patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and the changes of hemorheology, ET-1, and NIHSS score in the two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 79.49% and 87.18%, respectively, and there were differences between two groups (P < 0.05). After treatment, ESR, HCT, FIB, RF, and HBV in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And ESR, HCT, RF, and HBV in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, NIHSS scores and ET-1 in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly better than those in control group, with significant difference between two groups (P < 0.05). Conclusion Guhong Injection combined with Fasudil Hydrochloride Injection has clinical curative effect in treatment of ischemic cerebral infarction, and can significantly improve hemorheology, and can significantly reduce ET-1, which has a certain clinical application value.