| 猫耳刺皂苷ilexpernoside C抑制低密度脂蛋白多聚体诱导泡沫细胞形成的活性及机制研究 |
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| 引用本文： | 伦琦星,刘炳琳,李军,赵云芳,郑姣,屠鹏飞.猫耳刺皂苷ilexpernoside C抑制低密度脂蛋白多聚体诱导泡沫细胞形成的活性及机制研究[J].中国中药杂志,2016,41(3):498-503. |
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| 作者姓名： | 伦琦星 刘炳琳 李军 赵云芳 郑姣 屠鹏飞 |
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| 作者单位： | 北京中医药大学中药现代研究中心, 北京 100029;北京中医药大学中药学院, 北京 100102,北京中医药大学中药现代研究中心, 北京 100029;北京中医药大学中药学院, 北京 100102,北京中医药大学中药现代研究中心, 北京 100029,北京中医药大学中药现代研究中心, 北京 100029,北京中医药大学中药现代研究中心, 北京 100029,北京中医药大学中药现代研究中心, 北京 100029 |
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| 基金项目： | 国家自然科学基金项目(81503286);北京市自然科学基金项目(7144221) |
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| 摘 要： | 巨噬细胞来源的泡沫细胞在血管壁上的堆积,是动脉粥样硬化的主要成因。该实验构建了低密度脂蛋白多聚体(LDL aggregates)诱导的泡沫细胞模型,对冬青属植物猫耳刺分离的化合物进行体外活性研究,发现ilexpernoside C(IC1)能显著抑制泡沫细胞的形成。通过对泡沫细胞形成相关受体的分析发现,IC1能显著抑制低密度脂蛋白相关受体1(LRP1)的表达。因此,该研究认为皂苷IC1通过抑制巨噬细胞的胞吞作用,从而抑制泡沫细胞的形成,使其可能成为一种抗动脉粥样硬化的潜在药物。
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| 关 键 词： | 猫耳刺 ilexpernoside C 泡沫细胞 低密度脂蛋白多聚体 |
| 收稿时间： | 2015/8/10 0:00:00 |
Inhibitory effect of ilexpernoside C from Ilex pernyi on aggregated LDL-induced foam cells formation |
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| LUN Qi-xing,LIU Bing-lin,LI Jun,ZHAO Yun-fang,ZHENG Jiao and TU Peng-fei.Inhibitory effect of ilexpernoside C from Ilex pernyi on aggregated LDL-induced foam cells formation[J].China Journal of Chinese Materia Medica,2016,41(3):498-503. |
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| Authors: | LUN Qi-xing LIU Bing-lin LI Jun ZHAO Yun-fang ZHENG Jiao and TU Peng-fei |
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| Institution: | Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China;School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China,Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China;School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China,Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China,Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China,Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China and Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China |
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| Abstract: | The aggregation of macrophage-derived foam cells on vascular wall is considered to be a main cause of atherosclerosis. In the present study, we evaluated the inhibitory effect of the compound ilexpernoside C (IC1) extracted from Ilex pernyi (Aquifoliaceae) on foam cell formation in THP-1 macrophages cells which were induced by low density lipoproteins aggregates (LDL aggregates). Results showed that IC1 could significantly inhibit the formation of foam cells. The analysis on related receptors of foam cells indicated that IC1 could significantly decrease the expression of low density lipoprotein-related receptor 1(LRP1). Therefore, these findings indicated that IC1 inhibited the formation of foam cells by inhibiting endocytosis of macrophages, thus it may act as a potential anti-atherosclerotic agent. |
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| Keywords: | Ilex pernyi ilexpernoside C foam cell aggLDL |
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