2012-2014年南京地区34家医院抗真菌药物的使用情况分析

目的：了解南京地区34家医院2012—2014年抗真菌药物的使用情况和趋势，为临床合理用药提供参考。方法收集2012—2014年南京地区34家医院抗真菌药物的使用数据，对抗真菌药物的销售金额、用药频度（DDDs）等进行统计分析。结果2012—2014年南京地区34家医院抗真菌药物的总销售金额及构成比逐年上升。深部抗真菌药的用药金额远大于浅部抗真菌药，其中三唑类用药金额最大，其次是棘白菌素类。抗真菌药金额排序中三唑类药物排在前列，伏立康唑和氟康唑稳居第1、2位。浅表抗真菌药以特比萘芬为主，销售金额逐年下降。抗真菌药的DDDs排序中，深部抗真菌药中三唑类伊曲康唑排在前列，浅部抗真菌药克霉唑、硝呋太尔制霉素排名也居于前列。结论南京地区医院2012—2014年抗真菌药物的用药金额呈增长趋势，应加强对抗真菌药物的临床应用评价工作，从而促进抗真菌药的临床合理应用。

Analysis on utilization of antifungal drugs in 34 hospitals from Nanjing area during 2012-2014

Objective To investigate the use and trend of antifungal drugs in 34 hospitals from Nanjing area during 2012-2014, and to provide reference for reasonable application of antifungal drugs. Methods The data of antifungal drugs in 34 hospitals from Nanjing area during 2012-2014 were collected, sales amount, consumption sum, and the frequency of drug use (DDDs) were analyzed statistically. Results The total consumption sum and constituent ratio of antifungal drugs in 34 hospitals from Nanjing area during 2012-2014 increased yearly. Consumption sum of deep antifungal drugs were more than those of superficial antifungal drugs. The consumption sum of triazoles was the largest, and the next were echinocandins. In the consumption sum sequence of antifungal drugs, voriconazole and fluconazole in triazoles ranked the first and second. Superficial antifungal drugs were mainly consisted of terbinafine, while the consumption sum of that decreased yearly. In DDDs sequence of antifungal drugs, itraconazole in triazoles of antifungal drugs was ranked the first. In superficial antifungal drugs, clotrimazole and nifuratel nysfungin ranked the top. Conclusion The consumption sum of hospitals from Nanjing area has a tendency to increase. Therefore, clinical evaluation of antifungal drugs should be strengthened, and to promote reasonable application of antifungal drugs in clinic.