Molecular portrait of cisplatin induced response in human testis cancer cell lines based on gene expression profiles |
| |
| Authors: | Nur Duale Birgitte Lindeman Mitsuko Komada Ann-Karin Olsen Ashild Andreassen Erik J Soderlund Gunnar Brunborg |
| |
| Affiliation: | (1) Department of Chemical Toxicology, Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo, Norway |
| |
| Abstract: | Background Testicular germ cell tumors (TGCTs) respond well to cisplatin-based chemotherapy and show a low incidence of acquired resistance compared to most somatic tumors. The reasons for these specific characteristics are not known in detail but seem to be multifactorial. We have studied gene expression profiles of testicular and colon cancer derived cell lines treated with cisplatin. The main goal of this study was to identify novel gene expression profiles with their functional categories and the biochemical pathways that are associated with TGCT cells' response to cisplatin. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
