对氨基苯甲酸对变形链球菌表面疏水性的影响

目的　研究血链球菌合成的生态调节因子---对氨基苯甲酸(PABA)对变形链球菌细胞表面疏水性的影响,从而进一步了解PABA影响细菌粘附的机制。方法　在不同PABA浓度(10-9g/L、10-7g/L、10-4g/L)的改良Carls- son液体培养基中厌氧培养变形链球菌,并采用微生物粘着碳氢化合物法测试细胞表面疏水性。结果　低浓度的 PABA可增强变形链球菌细胞表面疏水性,当浓度增加到一定范围则可降低其细胞表面疏水性。结论　PABA可能通过降低细菌非特异性疏水作用而抑制变形链球菌的粘附。

Effect of Para-aminobenzonic Acid(PABA) on Cell-Surface Hydrophobicity of Streptococcus Mutans

Objective To study the effect of Para-aminobenzonic acid on cell-surface hydrophobicity of Streptococcus mutans.Methods Microbial adhesion to hydrocarbons (MATH) was used to measure the cell-surface hydrophobicity of Streptococcus mutans which grew in modified Carlsson medium with different dilutions of PABA.Results The cell-surface hydrophobicity of Streptococcus mutans increased when Carlsson medium contained low dilution of PABA. But following the increase of PABA, the cell-surface hydrophobicity decreased.Conclusion Para-aminobenzonic acid could inhibit the adherence of Streptococcus mutans through changing its cell-surface hydrophobicity.