格列吡嗪与格列齐特合治2型糖尿病的观察

目的：观察格列吡嗪与格列齐特合用是否可以更有效地控制2型糖尿病患者的血糖。方法：取63名患者，根据其一天中血糖变化分别服用格列吡嗪及格列齐特，监测血糖随时调整药量，4个月后将其各时段血糖及HbAlc与治疗前所检测结果进行统计学处理。结果：合用格列吡嗪与格列齐特4个月后各时段血糖及HbAlc控制基本达标，比治疗前的血糖及HbAlc有显著好转。结论：利用格列吡嗪与格列齐特作用时间和半衰期的不同，根据血糖波动情况分别服用，可达到良好控制血糖的目的。

Investigation on type 2 diabetes mellitus treatded by glipizide and gliclazide

Objective At different time during a day,glipizide and gliclazide were separately prescribed for patients suffering from type 2 diabetes mellitus,then examined their blood glucose,see whether a better control of it can be attained.Methods 63 patients were examined.Based on their respective varied curves of the changes of their blood glucose in a day,glipizide and gliclazide were separately prescribed,their blood glucose was investigated,and the doses should be timely adjusted.Four months later,their blood glucose and HbAlc of different periods of time together with those tested before the treatment were dealt with statistically.Results After the treatment for four months,the blood glucose and HbAlc of different periods of time were controlled,coming up to the standard in the main.There was an apparent improvement in the blood glucose and HbAlc,better than those before the treatment.Conclusions With the differences of the effective time and half life of glipizide and gliclazide,and in the light of the fluctuation of blood glucose,better control of blood glucose can be achieved,if taken separately.