前列地尔联合黄芪治疗糖尿病肾病疗效观察

目的 观察前列地尔联合黄芪治疗糖尿病肾病的临床疗效.方法 55例糖尿病肾病患者随机分为联合治疗组(27例)和对照组(28例),对照组单用前列地尔治疗,联合治疗组在此基础上加用黄芪,各组疗程均为2周,治疗前后检测和比较各种生化指标.结果 联合治疗组的治疗总有效率为81.5%,明显高于对照组71.4%(P<0.05);两组治疗后联合治疗组24 h-UAER和ALB较对照组下降明显(P<0.05).结论 前列地尔联合黄芪治疗治疗糖尿病肾病疗效显著,且无明显不良反应,值得临床推广.

Clinical study of alprostadil combined with astragalus in treatment of diabetic nephropathy

Objective To observe the clinical efficacy of alprostadil combined with astragalus In treatment of diabetic nephropathy.Methods 55 patients with diabetic nephropathy were randomly divided into combined treatment group（27 cases） and control group（28 ases）.The patients in the control group were only treated by alprostadil,while those in the combined treatment group were treated by astragalus on the basis of control group.The cure time of two groups was 2 weeks.The level of 24 h-UAER,Scr,BUN and ALB in two groups before and after treatment were detected and compared.Results The total effective rates of two groups were 81.5% and 71.4%,there was a significant difference between the groups（P0.05）;The level of 24 h-UAER,ALB in combined treatment group after treatment declined more significantly than that in control group（P0.05）.Conclusion The treatment of alprostadil combined with astragalus has a significant effect on the treatment of diabetic nephropathy and no adverse effects,it would be valuable to widespread popularization.