深圳市育龄女性促甲状腺激素水平升高与体质指数关系

目的:探讨深圳市育龄女性促甲状腺激素(TSH)水平升高与体质指数(BMI)的关系。方法:以2013年1月—2018年12月在深圳市参加国家孕前优生健康检查的256675例育龄女性为研究对象,通过问卷调查、体格检查、实验室检查收集相关信息,采用多因素Logistic回归模型分析育龄女性TSH水平升高与BMI的关联。结果:本研究纳入的256675例育龄女性中TSH水平升高者占3.4%;体重过低(BMI<18.5kg/m2)和超重/肥胖(BMI≥24.0kg/m2)者分别占20.0%和12.0%。多因素分析显示,与TSH水平正常组相比,TSH水平升高组女性超重/肥胖的风险增加29%(OR=1.29,95%CI 1.20~1.38),体重过低的风险降低13%(OR=0.87,95%CI 0.82~0.93)。结论:育龄女性TSH水平升高与BMI增大有关,将TSH水平控制在适当范围,可能会降低超重/肥胖的发生风险。

The study on the association between elevated thyroid stimulating hormone level and body mass index of reproductive age women in Shenzhen

Objective:To explore the association between elevated thyroid stimulating hormone(TSH)level and body mass index(BMI)of reproductive age women in Shenzhen.Methods:A total of 256675 reproductive age women who had participated in the National Pre-pregnancy Health Examination Program in Shenzhen from January 2013 to December 2018 were selected as the research objects.The relevant information about physical examination and laboratory examination of these research objects were collected by questionnaire.The multivariate logistic regression model was used to analyze the association between BMI and elevated TSH level of reproductive age women.Results:In these 256675 reproductive age women,the women with elevated TSH level accounted for 3.39%,the women with underweight(BMI<18.5kg/m2)accounted for 20.03%,and the women with overweight/obese(BMI≥24.0kg/m2)accounted for 11.99%.The multivariate analysis showed that compared with those of women with normal TSH level,the risk of overweight/obese of women with elevated TSH level had increased by 29%(OR=1.29,95%CI:1.20-1.38),and the risk of underweight of women with elevated TSH level had decreased by 13%(OR=0.87,95%CI:0.82-0.93).Conclusion:Elevated TSH level of reproductive age women was positively associated with BMI increased,so keeping TSH level in an appropriate range might reduce the risk of overweight/obese of reproductive age women.