芳香疗法预防肿瘤患者化疗后恶心及呕吐的系统评价

目的评价芳香疗法对肿瘤患者化疗后恶心、呕吐的预防效果。方法检索数据库包括PubMed、WebofScience、Cochrane Library、Embase、CINAHL、知网、维普、万方和中国生物医学文献数据库,检索时限为从建库至2019年7月17日,收集芳香疗法预防肿瘤患者化疗后恶心、呕吐的随机对照试验,评价和提取信息后,采用RevMan5.3软件进行分析。结果共纳入10篇文献,共计1267例患者,按评估量表的种类分别进行Meta分析。在芳香疗法预防急性恶心的效果分析中,以视觉模拟评分量表(visual analogue scale,VAS)为结局指标的分析结果为[MD=-7.26,95%CI(-13.22,-1.31),P=0.02];以恶心、呕吐、干呕评分为结局指标的分析结果为[MD=-1.05,95%CI(-1.55,-0.55),P<0.0001];以急性恶心的发生率为结局指标的分析结果为[RR=0.69,95%CI(0.52,0.91),P=0.009]。芳香疗法预防急性干呕效果的分析结果为[MD=-0.59,95%CI(-0.97,-0.21),P=0.002],预防延迟性干呕效果的分析结果为[MD=-0.93,95%CI(-1.54,-0.31)=0.003]。结论芳香疗法对化疗后急性恶心、急性干呕及延迟性干呕的预防效果显著优于对照组,对其他时期恶心、呕吐的预防效果仍需要进一步验证。

Aromatherapy for Preventing Chemotherapy Induced Nausea and Vomiting in Cancer Patients:A Systematic Review

Objective To evaluate the effects of aromatherapy on Chemotherapy Induced Nausea and Vomiting(CINV)in cancer patients.Methods This study searched the following databases.including PubMed.Web of Science.Cochrane Library.Cl N AH L.Embase.VIP.CNKI.CBM.and WanFang Data.The retrieval time was from the establish ment of the database to July 17.2019.The randomized controlled trials of aromatherapy to prevent CINV in cancer pa-tients were collected.After evaluation and extraction of information.Revman 5.3 software was used for analysis.Results A total of 10 randomized controlled trials(RCTs)with 1267 patients recruited.Meta-analysis was conducted accord ing to the type of evaluation scale.For the effect of aromatherapy on the prevention of acute nausea.the results of the study with VAS as the outcome indicator were MD=-7.26[95%CI(-13.22.1.31).P=0.02].The results of the study with INVR as the outcome indicator were MD=-1.05[95%CI(-1.55.-0.55).P<0.0001].The results of the study with incidence of acute nausea as the outcome indicator were RR’0.69[95%CI(0.52.0.91).P=0.009].For the effect of aromatherapy on preventing retching,the results of the effect on preventing acute retching were MD=-0.59[95%CI(0.97.0.21).P=0.002].and the results of the effect on preventing delayed retching were MD'0.93[95%CI(1.54.0.31).P=0.003].Conclusions The preventive effect of aromatherapy on chemotherapy in duced acute nausea.acute vomiting and delayed vomiting was significantly better than that of the control group.and the preventive effect on other periods of nausea and vomiting still needs to be further verified.