自身免疫性卵巢早衰患者血清TBP2、BMP15的临床意义

目的:探讨硫氧还蛋白结合蛋白-2(TBP2)、骨形态发生蛋白15(BMP15)在自身免疫性卵巢早衰(POF)患者血清表达情况及临床意义。方法:选取本院收治的48例自身免疫POF患者为病例组,同期体检卵巢功能正常女性48例为正常组,酶联免疫吸附法检测其血清TBP2、BMP15,化学发光法检测性激素水平,分析二者变化对自身免疫性POF的临床意义。结果:病例组血清中TBP2、BMP15表达水平均低于正常组,卵泡刺激素(FSH)、黄体生成素(LH)水平高于正常组,雌二醇(E2)水平低于正常组(均P<0.05);病例组血清TBP2、BMP15表达与FSH、LH呈负相关性,与E2水平呈正相关性(均P<0.05),TBP2与BMP15表达呈正相关性(P=0.000)。结论:自身免疫性POF患者血清TBP2、BMP15表达下调,二者表达呈正相关性,并与患者性激素水平相关。可能TBP2、BMP15相互协同调控自身免疫POF发病过程。

The clinical significance of TBP2 and BMP15 levels in autoimmune premature ovarian failure

Objective:To investigate the expressions and clinical significance of thioredoxin binding protein-2(TBP2)and bone morphogenetic protein 15(BMP15)in autoimmune premature ovarian failure(POF).Methods:48 women with autoimmune POF were selected in study group,and 48 healthy women with normal ovarian function were selected in control group during the same period.The enzyme linked immunosorbent assay(ELISA)was used to detect the expression levels of TBP2 and BMP15 of all subjects,and the levels of sex hormone was detected by Abbott I2000 chemiluminescence analyzer.The clinical significance of the changes of the levels of TBP2 and BMP15 in autoimmune POF was analyzed.Results:The levels of TBP2 and BMP15,and the level of estradiol(E2)of women in the study group were significant lower than those of women in the control group(P<0.05),but the levels of follicle stimulating hormone(FSH)and luteinizing hormone(LH)of women in the study group were significant higher(all P<0.05).In the study group,the expressions of TBP2 and BMP15 were negatively correlated with the levels of FSH and LH,but were positively correlated with the level of E2(P<0.05).There was a positive correlation between TBP2 expression and BMP15 expression(P=0.000).Conclusion:The expression levels of TBP2 and BMP15 of women with autoimmune POF are down-regulated,and there is a positive correlation between the TBP2 expression and the BMP15 expression.And the expression levels of TBP2 and BMP15 is closely related to the levels of sex hormone,which means TBP2 level and BMP15 level maybe synergistically regulate the pathogenesis of autoimmune POF.