多囊卵巢综合征患者妊娠早期血清Resistin水平与不良妊娠结局

目的:探讨多囊卵巢综合征(PCOS)孕妇妊娠早期血清抵抗素(Resistin)表达特征及与不良妊娠关系。方法:选取54例PCOS孕妇和100例健康孕妇分别作为病例组与对照组。在孕早期行血清Resistin、性激素结合球蛋白(SHBG)、空腹血糖(FPG)、空腹胰岛素(FINS)水平检测并分析与不良妊娠结局关系。结果:病例组血清Resistin、HOMA-IR值均高于对照组,SHBG水平低于对照组(P<0.05)。病例组妊娠结局良好者的Resistin、HOMA-IR水平均低于不良者,SHBG水平高于不良者(P<0.05)。病例组不良妊娠结局与妊娠早期血清Resistin、HOMA-IR水平呈正相关(r=0.416、0.316,P<0.05),与血清SHBG水平呈负相关(r=-0.307,P<0.05),血清Resistin水平相关程度最强。结论:PCOS孕妇妊娠早期血清Resistin水平升高且与妊娠并发症、不良妊娠结局有正相关关系,SHBG和HOMA-IR也可作为预测PCOS患者不良妊娠结局的参考指标。

Relationship between serum Resistin level and adverse pregnancy outcomes of pregnant women with polycystic ovary syndrome during the first trimester pregnancy

Objective:To investigate the expression characteristics of serum Resistin of pregnant women with polycystic ovary syndrome(PCOS)during the first trimester pregnancy,and to analyze its correlation with adverse pregnancy outcomes.Methods:54 pregnant women with PCOS were selected in study group,and 100 healthy pregnant women were selected in control group.The levels of serum resist,sex hormone binding globulin(SHBG),fasting blood glucose(FPG),and fasting insulin(FINS)of women during the first trimester pregnancy in the two groups were measured,and their correlation with adverse pregnancy outcomes was analyzed.Results:The serum Resist level and HOMA-IR value of women in the study group were significant higher than those of women in the control group,but serum SHBG level was significant lower(P<0.05).In the study group,the serum Resist level and HOMA-IR value of women with good pregnancy outcomes were significant higher than those of women with adverse pregnancy outcomes,but serum SHBG level was significant lower(P<0.05).Correlation analysis showed that the adverse pregnancy outcomes of women in the study group were positively correlated with serum Resist level and HOMA-IR value during the first trimester pregnancy(r=0.416,0.316,P<0.05),but were negatively correlated with serum SHBG level(r=-0.307,P<0.05).The serum Resist level of women in the study group was most strongly associated with adverse pregnancy outcomes.Conclusion:The serum Resist level of pregnant women with PCOS significantly increases during the first trimester pregnancy,which is positively correlated with pregnancy complications and adverse pregnancy outcomes.The SHBG level and HOMA-IR value can also be used as reference indicators for predicting adverse pregnancy outcomes of women with PCOS.