门冬胰岛素注射液联合运动疗法治疗妊娠期糖尿病效果及对胎儿脐、肾动脉血流动力学影响

目的:分析门冬胰岛素注射液联合运动疗法治疗妊娠期糖尿病(GDM)疗效及对胎儿脐、肾动脉血流动力学指标影响。方法:纳入本院2017年1月-2019年1月收治的GDM患者116例,随机分为2组,对照组58例采纳二甲双胍联合运动疗法治疗,观察组58例采纳门冬胰岛素注射液联合运动疗法治疗,两组均接受治疗直至分娩,对比两组临床疗效、血糖指标、脐、肾动脉血流动力学指标、不良妊娠结局发生率。结果:治疗后观察组临床总有效率(96.6%)高于对照组(75.9%),2h血糖及空腹血糖水平均低于对照组,脐、肾动脉阻力指数以及S/D水平均低于对照组,不良妊娠结局发生率(3.5%)低于对照组(25.9%)(均P<0.05)。结论:门冬胰岛素注射液联合运动疗法可更有效降低GDM患者血糖,改善胎儿肾、脐动脉RI、S/D,改善妊娠结局。

Effect of insulin aspart injection combined with exercise therapy for treating pregnant women with GDM and its influence on hemodynamic parameters of fetal umbilical and renal arteries

Objective:To analyze the clinical efficacy of insulin aspart injection combined with exercise therapy for treating pregnant women with gestational diabetes mellitus(GDM),and to study its influence on hemodynamic parameters of fetal umbilical cord and renal artery.Methods:A total of 116 pregnant women with GDM were randomly divided into two groups from January 2017 to January 2019.58 patients in the control group were treated by metformin combined with exercise therapy until delivery,and 58 patients in the experimental group were treated by insulin aspart injection combined with exercise therapy until delivery.The clinical efficacy,blood glucose indexes,umbilical and renal artery hemodynamics indicators,and rate of adverse pregnancy outcomes of women were compared between the two groups.Results:The total clinical effective rate of women in the experimental group was 96.6%,which was significant higher than that(75.9%)of women in the control group.The 2hPG and FPG levels and the values of umbilical and renal artery RI and S/D of women in the experimental group were significant lower than those of women in the control group.The incidence of adverse pregnancy outcomes of women in the experimental group was 3.5%,which was significant lower than that(25.9%)of women in the control group(all P<0.05).Conclusion:Insulin aspart injection combined with exercise therapy can effectively reduce blood glucose level of pregnant women with GDM,and can improve their fetal kidney and umbilical artery RI,S/D values,so it can improve the pregnancy outcomes.