Pathophysiology of ischemic heart disease |
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| Authors: | W B Hood |
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| Affiliation: | Thorndike Memorial Laboratory, Harvard Medical Unit, Boston City Hospital, and the Department of Medicine, Harvard Medical School, Boston, Mass., USA |
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| Abstract: | Recent clinical and experimental studies have helped to clarify the pathophysiology of acute and chronic coronary insufficiency, particularly in the area relating myocardial ischemia to abnormal function of the damaged left ventricle. When proximal vessel stenosis due to coronary atherosclerotic disease becomes the major locus of resistance to coronary blood flow, there is a decline in perfusion pressure distal to the stenosis. This results in ischemia when the normal mechanism for autoregulating coronary flow (i.c., coronary arteriolar vasodilatation) is no longer adequate to maintain flow. |
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