补肾强督方治疗强直性脊柱炎患者259例临床研究

目的：探讨补肾强督方治疗强直性脊柱炎（AS）的临床疗效与安全性.方法：本研究共入选259例门诊和住院患者,予补肾强督方治疗,每日1剂,早晚分服,疗程6个月,治疗前后评价如下疗效指标：患者健康综合评分（BAS-G）、疾病活动指数（BASDAI）、功能指数（BASFI）、全身痛Likert四级评分、脊柱痛Likert四级评分、晨僵时间、医生总体评价、枕墙距、指地距、颌柄距、胸廓活动度、Schober征、脊柱活动度、＂4＂字试验、血沉（ESR）、C反应蛋白（CRP）,并观察血常规、尿常规、肝肾功能等药物安全性指标.结果：259例患者经用补肾强督方治疗6个月后,除枕墙距、颌柄距无明显改变外,其余指标均有显著改善.259例患者均未出现血常规、尿常规改变及肝肾功能损害.结论：补肾强督方对AS有较好疗效,且安全可靠.

Clinical Study on Bushen Qiangdu Recipe for Treatment of 259 Cases of Ankylosing Spondylitis

Objective:To explore clinical therapeutic effect and safety of Bushen Qiangdu Recipe on ankylosing spondylitis(AS).Methods:259 out-patients and in-patients enrolled were treated with Bushen Qiangdu Recipe for 6 months,one dose each day for oral administration in morning and night.BAS-G,BASDAI,BASFI,Likert' 4-grade score of spinal pain,Likert' 4-grade score of whole body pain,duration of morning stiffness,evaluation of doctor,the occiput-wall distance,the finger-floor distance,the mandible-stermum distance,chest expansion,Schober' test,the range of spinal movement,Gaenslen's sign,ESR,CRP,blood and urine routine examination,renal and hepatic functions were detected before and after treatment.Results:Significant improvement was observed in all indexes except for the occiput-wall distance and the mandible-stermum distance,and no adverse effect in blood and urine routine examination and renal and hepatic function was found.Conclusion:Bushen Qiangdu Recipe has therapeutic effect on ankylosing spondylitis.