| MORPHOMETRIC ANALYSIS AND MODEL ASSESSMENT OF GASTRIC CARCINOMA AND PRECANCEROUS LESIONS OF STOMACH |
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| 作者姓名： | 庄亚华 赵明朗 王瑞年 姚志洪 苏炳华 |
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| 作者单位： | Department of Pathology，College of Bosic Medical Sciences，SSMU，Shanghai，Department of Pathology，College of Bosic Medical Sciences，SSMU，Shanghai，Department of Pathology，College of Bosic Medical Sciences，SSMU，Shanghai，Institute of Biomedical Engineering，College of Basic Medical Sciences，SSMU，Shanghai，Depatment of Mathematics，College of Basic Medical Sciences，SSMU，Shanghai |
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| 摘 要： | Ninety-four pathologic specimens of gastric mucosa with lesions including simple intestinal metaplasia, intestinal types of mild, moderate, severe dysplasia and gastric carcinoma were submitted to morphometric analysis by an automated image analysis system. Four kinds of indices and four geometric parameters were measured. They were: (1) Index of Structural Atypism (ISA); (2) Index of Glandular Formation (IGF); (3) Index of Nuclei-Gland ratio (ING); (4) Widthen of Nuclear Band (WNB); (5) Geometric parameters of cell nuclei: including Area, Perimeter, Mean Diameter, and Contour. Apart from Contour, these variables were increased with increasing degrees of atypism in the various types of gastric mucosal lesions. Hence the indices and parameters may be used as objective diagnostic criteria. An assessment model was established for discriminating various types of lesions. The coincidence rate between the model assessment and the original histopathologic diagnosis was 86.1%. Morphometric analysis may provide a means of standardizing pathologic diagnosis and grading of gastric precancerous lesions.
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MORPHOMETRIC ANALYSIS AND MODEL ASSESSMENT OF GASTRIC CARCINOMA AND PRECANCEROUS LESIONS OF STOMACH |
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| Zhuang Yahua Zhao Minglang Wang Ruinian.MORPHOMETRIC ANALYSIS AND MODEL ASSESSMENT OF GASTRIC CARCINOMA AND PRECANCEROUS LESIONS OF STOMACH[J].Journal of Shanghai Second Medical University(Foreign Language Edition),1990(1). |
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| Authors: | Zhuang Yahua Zhao Minglang Wang Ruinian |
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| Institution: | Zhuang Yahua Zhao Minglang Wang Ruinian Department of Pathology,College of Bosic Medical Sciences,SSMU,Shanghai Yao Zhihong Institute of Biomedical Engineering,College of Basic Medical Sciences,SSMU,Shanghai Su Binghua Depatment of Mathematics,College of Basic Medical Sciences,SSMU,Shanghai |
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| Abstract: | Ninety-four pathologic specimens of gastric mucosa with lesions including simple intestinal metaplasia, intestinal types of mild, moderate, severe dysplasia and gastric carcinoma were submitted to morphometric analysis by an automated image analysis system. Four kinds of indices and four geometric parameters were measured. They were: (1) Index of Structural Atypism (ISA); (2) Index of Glandular Formation (IGF); (3) Index of Nuclei-Gland ratio (ING); (4) Widthen of Nuclear Band (WNB); (5) Geometric parameters of cell nuclei: including Area, Perimeter, Mean Diameter, and Contour. Apart from Contour, these variables were increased with increasing degrees of atypism in the various types of gastric mucosal lesions. Hence the indices and parameters may be used as objective diagnostic criteria. An assessment model was established for discriminating various types of lesions. The coincidence rate between the model assessment and the original histopathologic diagnosis was 86.1%. Morphometric analysis may provide a means of standardizing pathologic diagnosis and grading of gastric precancerous lesions. |
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| Keywords: | gastric carcinoma precancerous lesions pathology morphometric analysis assessment model |
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