| The Protein Expression of Bcl-2, Bax, Fas/Apo-1 in Acute Myeloid Leukemia |
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| 作者姓名： | 周剑锋 陈燕 李崇渔 刘文励 |
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| 作者单位： | ZHOU Jianfeng; LIU Wenli (Department of Hematology，Tongji Hospital，Tongji Medical University，Wuhan 430030)CHEN Yan; LI Chongyu (Institute of Hematology，Tongji Medical University，Wuhan 430022) |
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| 摘 要： | Homeostasisof11ematopoiesisiscontrollednotoillybytheproliferationanddifferentiationofcells,butalsobycelldeath.Inadditiontolossofcontrolofcellproliferation,disruptionofapoptosis--inducedflnctionalsocontributestotumordevelopment.Althoughdiversesignalscaninduceapoptosisinawidevarietyofcelltypes,anumberofevolutionarilyconservedgenesregulateafinalcommoncelldeathpathway,thatisconservedinmanyspeciesfromwormstohumansll].Thehcf--2proto--oncogeneisoneofthecrucialapoptosisantagonizinggenes.Highlevelofhc…
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| 收稿时间： | 5 July 1997 |
The protein expression of bcl-2, bax, Fas/Apo-1 in acute myeloid leukemia |
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| Zhou Jianfeng M. D., Ph. D.,Chen Yan,Li Chongyu,Liu Wenli.The Protein Expression of Bcl-2, Bax, Fas/Apo-1 in Acute Myeloid Leukemia[J].Journal of Zuazhong University of Science and Technology: Medical Edition,1998,18(1):42-45. |
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| Authors: | Zhou Jianfeng M D Ph D Chen Yan Li Chongyu Liu Wenli |
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| Institution: | (1) Department of Hematology, Tongji Hospital, Tongji Medical University, 430030 Wuhan;(2) Institute of Hematology, Tonhji Medical University, 430022 Wuhan |
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| Abstract: | The protein expression of bcl-2, bax, Fas/Apo-1 in 19 cases of acute myeloid leukemia (AML) were investigated by Western blot and APAAp techniques. High expression of bcl-2 protein was found in most of the AML cases,and some of the cases expressed Fas/Apo-1 and bax. High expression of bcl-2 protein was associated with a bad clinical prognosis and a poor response after intensive chemotherapy. Bax seemed to coexpress with bcl-2 and so appeared to be a bad prognostic factor instead of a good one. The expression of Fas/Apo-1 was inversely correlated with hcf-2 and seemed to be a good prognostic factor which may reflect the relative homeostasis of apoptotic pathway. It is concluded that apoptosis-induced pathways in AML often exhibit disturbance features. Coregulation of bcl-2, Bax and Fas/Apo-1 genes formed the apoptosis-induced pathway,which is the biological factor affecting response to chemotherapy. |
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| Keywords: | apoptosis bcl-2 Fas/Apo-1 bax AML |
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