前白蛋白在急性心肌梗死患者中的变化及与预后的关系

目的探讨血清前白蛋白水平在急性心肌梗死(AMI)患者中的变化及与病变严重程度的关系,为该病的诊治及病情监测提供依据。方法选取AMI患者103例(AMI组),根据冠状动脉造影结果分为单支病变34例、2支病变36例和3支病变33例;同时根据是否发生心血管事件分为发生心血管事件31例和未发生心血管事件72例;另随机选取同期健康体检者40例为对照组。应用免疫投射比浊法检测2组血清前白蛋白水平。结果与对照组比较,AMI组血清前白蛋白水平明显降低,差异有统计学意义(0.22±0.06)g/L vs(0.28±0.06)g/L,P<0.05];对照组无前白蛋白异常,AMI组为33.01%(P<0.05);随病变支数增加,单支病变、2支病变和3支病变患者前白蛋白水平逐渐下降,差异有统计学意义(0.24±0.06)g/L vs(0.22±0.06)g/L vs(0.19±0.05)g/L,P<0.05];Spearman相关分析显示,前白蛋白水平与冠状动脉病变程度呈负相关(r=-0.206,P<0.05)。结论 AMI患者前白蛋白水平明显降低,且病变越严重前白蛋白水平越低,其病变严重程度可能与其预后有关,可作为AMI患者病情监测及预后判断的指标。

Relation between serum prealbumin level and outcomes in acute myocardial infarction patients

Objective To provide the evidence for the diagnosis and treatment of acute myocardial infarction(AMI)by studying the relation between serum prealbumin level and AMI.MethodsOne hundred and three AMI patients served as an AMI group and 40 subjects undergoing physical examination served as a control group in this study.Patients in AMI group were divided into single vascular lesion group(n=34),double vascular lesion group(n=36),and triple vascular lesion group(n=33).The serum prealbumin levels were measured in AMI group and control group by immune projection turbidimetry.Results The serum prealbumin level was significantly lower while the incidence of abnormal prealbumin was significantly higher in AMI group than in control group(0.22±0.06g/L vs 0.28±0.06g/L,P<0.05;33.01%vs 0%,P<0.05).The serum prealbumin level was significantly lower in single,double and triple vascular lesion groups than in control group(0.24±0.06g/L vs 0.19±0.05g/L,0.22±0.06g/L vs 0.19±0.05g/L,P<0.05).Spearman correlation analysis showed that the serum prealbumin level was negatively related with the coronary artery lesions(r=-0.206,P<0.05).Conclusion The serum prealbumin level decreases significantly with coronary artery lesions and can thus predict the outcomes in AMI patients.