| 荆芥挥发油对白三烯拮抗活性的实验研究 |
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| 引用本文： | 曾南,李军晖,付田,沈映君.荆芥挥发油对白三烯拮抗活性的实验研究[J].中华中医药学刊,2006,24(6):1033-1035. |
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| 作者姓名： | 曾南 李军晖 付田 沈映君 |
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| 作者单位： | 成都中医药大学药学院药理教研室,四川,成都,610075 |
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| 摘 要： | 目的:观察荆芥挥发油(Sto)对白三烯类炎症介质的影响,探讨其抗炎作用机理。方法:角叉菜胶制备大鼠急性胸膜炎炎症模型,荆芥挥发油连续预防给药7天,ELISA法测定模型大鼠血清中LTB4含量;大鼠连续灌胃给予荆芥挥发油7天,制备腹腔白细胞悬液,加入外源性花生四烯酸,RP-HPLC法测定LTB4和LTC4的生成含量。结果:荆芥挥发油0.2、0.1mL/kg能明显降低模型大鼠血清LTB4含量,0.2mL/kg能显著减少花生四烯酸代谢产物LTB4和LTC4的生成。结论:荆芥挥发油具有拮抗白三烯活性的作用,是其良好抗炎作用的机制之一。
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| 关 键 词： | 荆芥挥发油 抗炎 白三烯B4 白三烯C4 |
| 文章编号： | 1009-5276(2006)06-1033-03 |
| 修稿时间： | 2005年12月7日 |
Effect of Jingjie Volatile Oil on Leukotrienes levels in Rats |
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| Zeng Nan,Li Junhui,Fu Tian,Shen Yingjun.Effect of Jingjie Volatile Oil on Leukotrienes levels in Rats[J].Chinese Archives of Traditional Chinese Medicine,2006,24(6):1033-1035. |
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| Authors: | Zeng Nan Li Junhui Fu Tian Shen Yingjun |
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| Abstract: | Objective:To study the effect of Jingjie Volatile Oil(Sto)on leukotrienes levelsin vivoand ex vivo as well as the mechanism of anti-inflammatory action of Sto.Methods:The rats were administrated with Sto for 7 days.The LTB_(4)of serum in carrageenan-induced acute inflammation in rats were measured by ELISA,and the levels of LTB_(4)and LTC_(4)in rat leucocyte were determined with RP-HPLC ex vivo.Results: Sto(0.2,0.1mL/kg)significantly decreased the concentration of leukotrieneB_(4)(LTB_(4)) in serum in carrageenan-induced acute inflammation in rats,Sto(0.2mL/kg) decreased the metabolites concentration of arachidonic acid in leucocyte sample resulted from abdominal cavityin rats that pre-treated with Sto.Conclusion: It suggests that the anti-inflammatory effects of Sto,due to its suppression effect on metabolismof arachidonic acid(AA),may allow it to alleviate the inflammation symptoms. |
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| Keywords: | jingjie volatile oil anti-inflammation leukortienesB_(4) leukortienesC_(4) |
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