肝动脉化疗栓塞联合三维适形放疗治疗原发性肝癌40例

目的:探讨肝细胞性肝癌(HCC)的肝动脉化疗药物栓塞(TACE)联合三维适形放疗(3DCRT)的综合治疗效果.方法:原发性肝癌患者76例,进行前瞻性分组研究,综合治疗组40例行TACE结合3DCRT治疗,对照组36例单纯行TACE治疗.结果:综合治疗组1,2,3年生存率分别为78%,60%,34%;对照组分别为50%,32%,18%(P<0.05).结论:对不能手术切除治疗的原发性肝癌患者,TACE结合3DCRT治疗能明显提高治疗疗效,且无严重毒副作用.

Prospective randomized clinical study of transcatheter arterial chemoembolization,combined with three dimensional conformal radiotherapy for primary liver cancer:an analysis of 40 cases

AIM:To study the effect of transcatheter arterial chemoembolization(TACE)combined with three-dimensional conformal radiotherapy (3DCRT)on inoperable primary liver cancer. METHODS:Patients were prospectively ran- domized into a TACE 3DCRT group(combined group,40 patients)and a TACE therapy alone group(TACE group,36 patients). RESULTS:The overall 1-,2-and 3-year survival rate was 78%,60% and 34% in the combined group,and 50%,32% and 18% in the TACE group.The difference between the two groups was significant(P<0.05). CONCLUSION:TACE 3DCR is more effective than TACE therapy alone on inoperable primary liver cancer,without inflicting more treatment- related toxicity.