| 黄连素对血小板聚集和释放的抑制作用 |
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| 引用本文： | 储钟禄 姜云飞. 黄连素对血小板聚集和释放的抑制作用[J]. 第二军医大学学报, 1989, 10(4): 323-327 |
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| 作者姓名： | 储钟禄 姜云飞 |
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| 作者单位： | 第二军医大学生物化学教研室(储钟禄，姜云飞，王智慧，宋春桥)，第二军医大学生物化学教研室(徐志平) |
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| 摘 要： |
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| 关 键 词： | 黄连素 血小板 聚集 抑制 |
EFFECTS OF BERBERINE ON PLATELET AGGREGATION AND RELEASE |
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| Chu Zhonglu,et al. EFFECTS OF BERBERINE ON PLATELET AGGREGATION AND RELEASE[J]. Former Academic Journal of Second Military Medical University, 1989, 10(4): 323-327 |
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| Authors: | Chu Zhonglu et al |
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| Affiliation: | Department of Biochemistry |
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| Abstract: | We have discovered that bcrberine (BR) is an anti-platelet drug.It was demonstrated that BR inhibited ADP-, arachidonate-, collagen-and calcium ionophorc A231S7-xnduced platelet aggregation and ATP release in different degrees.Especially BR strongly inhibited collagen-induced platelet aggregation and ATP release reaction(IC50 values were 0.12 and 0.08 mmol/L,respectively).The antiplatekt mechanism of BR may be inhibition of arachidonate metabolism,, and suppression of the rise of intracdlular Ca2' and/or cAMP levels.Because the platelet thrombus foimation in the arteries of brain and heart is closely related to the subendothelial collagen fibrils, BR may be an effective drug for the patients with these diseases. |
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| Keywords: | berberinc antiplatelet drug platelet inducer platelet shape change platelet aggregation platelet release reaction |
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