艾司佐匹克隆对健康受试者血压的影响

目的：分析单次口服艾司佐匹克隆对健康受试者血压的影响。方法：选择18～45岁之间的健康受试者26例，随机分为1．8，3．75，7．5，11．25和15．0mg共5个剂量组。对服药后1，4，8h的血压进行监测和24h，7d随访。结果：受试者的血压在服药后呈下降趋势，服药后各时间点的血压与服药前比较差异均有显著性统计学差异（P〈0．05）；最大下降幅度为25mmHg。血压降低较明显者主要集中在服药后1～4h。11例（42．3％）受试者出现收缩压或舒张压下降〉20％的情况，11．25～15mg剂量组发生率为58．3％（7／12），高于较低剂量组的发生率（28．6％，4／14）。在11．25～15mg剂量组，有3例血压降低〉20％的受试者出现了“头晕”的不良反应。结论：应关注艾司佐匹克隆对血压的潜在影响。

The influence of eszopiclone treatment on blood pressure in healthy volunteers

Objective:To analyze the effect of single dose eszopiclone treatment on blood pressure in healthy volunteers.Methods:Twenty-six subjects were involved in the study.They were randomized into 5 subgroups with eszopiclone dosage 1.8 mg,3.75 mg,7.5 mg,11.25 mg and 15.0 mg.The blood pressures were measured at 1 h,4 h,8 h,24 h and 7 d after eszopiclone treatment.Results:The blood pressures were decreased statistically significantly(P<0.05).It happened at 1 h and 4 h after treatment.There were 11 subjects(42.3%) whose decreased rate of systolic or diastolic blood pressure were up to 20%,and the incidence in 11.25 mg~15.0mg subgroup(58.3%,7/12) were higher than that of in the low-dose subgroup(28.6%,4/14).Three of these subjects in 11.25 mg~15.0 mg had the adverse reaction of dizziness.Conclusion:More attention should be paid to the possible effects of eszopiclone on blood pressure.