上海市某医院产妇乳汁中多溴联苯醚暴露水平

目的 通过对上海市某医院产妇乳汁中多溴联苯醚(PBDEs)含量的测定和分析,了解该地区人群中PBDEs的暴露水平及其相关影响因素.方法 于2006年9月至2007年4月在上海市某医院对48名产妇进行问卷调查,并采集其乳汁样本,产妇均为单胎妊娠,排除高血压、糖尿病、HIV感染和不良用药史.采用气相色谱-负化学电离源-质谱法测定乳汁中7种PBDE同族体[溴代联苯醚(BDE)-28,BDE-47,BDE-100,BDE-99,BDE-154,BDE-153和BDE-183]的含量,并分析其影响因素.结果 产妇乳汁中7种PBDEs(∑,PBDEs)浓度中位数为8.81 ng/g脂重(lipid weight,1w),浓度范围为1.92-41.55 ng/g 1w.BDE-28、BDE-47、BDE-100、BDE-99、BDE-154、BDE-153、BDE-183检出率分别为98%(47/48)、96%(46/48)、86%(41/48)、90%(43/48)、83%(40/48)、98%(47/48)、90%(43/48);浓度中位数分别为0.88、0.99、0.97、1.39、1.14、2.17、1.41 ng/g 1w.不同学历产妇乳汁中PBDEs水平(logΣ7PBDEs)分别为:初中及以下为(0.89±0.24)、高中为(1.02±0.17)、大专及以上为(1.08±0.28);不同月收入水平产妇乳汁中PBDEs水平(log∑7PBDEs)分别为:＜1000元为(0.89±0.12)、1000-3000元为(1.01±0.24)、＞3000元为(1.13±0.21).相关分析发现母亲受教育水平(r=0.322,P＜0.05)和收入水平(r=0.388,P＜0.05)与母乳PBDEs暴露水平呈正相关.结论 产妇乳汁中普遍含有PBDEs,母亲受教育水平和收入水平可能影响母乳中PBDEs水平.

Abstract：

Objective To measure the concentration of polybrominated diphenyl ethers(PBDEs)in human breast milk from a hospital in Shanghai and analyze the influencing factors.Methods Forty-eight puerperas from a hospital in Shanghai were selected to answer a questionnaire.and their breast milk samples were collected from September 2006 to April 2007.All the puerperas were singleton pregnancies.excluding high blood pressure.diabetes,HIV infection and adverse medical history.Seven congenera(BDE-28,BDE47,BDE-100,BDE-99,BDE-154,BDE-153 and BDE-183)were measured by gas chromatography-negative chemical ionization-mass spectrometry and the influencing factors were analyzed.Results The median of total PBDEs concentration in breast milk was 8.81 ng/g lipid weight(1w),and the range was 1.92-41.55,,g/g 1W. The detection rates of seven congeners(BDE-28,BDE-47,BDE-100,BDE-99,BDE-154,BDE-153,BDE-183)were 98%(47/48),96%(46/48),86%(41/48),90%(43/48),83%(40/48),98%(47/48),90%(43/48),and the median of them was,0.88,0.99,0.97,1.39,1.14,2.17,1.41 ng/g 1w,respectively.LogΣ7PBDEs in breast milk from mothers with different education levels were divided into junior high school or lower(0.89 ±0.24),senior high school(1.02±0.17),junior college or higher(1.08±0.28).LogΣ7PBDEs in breast milk from mothers with different income levels were divided as ＜1000 yuan(0.89±0.12),1000-3000 yuan(1.01±0.24),＞3000 yuan(1.13±0.21).Correlation analysis showed that both the mothers'education level(r=0.322.P＜0.05)and income level(r=0.388.P＜0.05)have a positive correlation to PBDEs levels in breast milk. Conclusion It is very common to detect PBDEs in human breast-milk.however,the education and income levels of the mothers my be the influencing factors.

Levels of polybrominated diphenyl ethers in human breast milk from a hospital in Shanghai

Objective To measure the concentration of polybrominated diphenyl ethers(PBDEs)in human breast milk from a hospital in Shanghai and analyze the influencing factors.Methods Forty-eight puerperas from a hospital in Shanghai were selected to answer a questionnaire.and their breast milk samples were collected from September 2006 to April 2007.All the puerperas were singleton pregnancies.excluding high blood pressure.diabetes,HIV infection and adverse medical history.Seven congenera(BDE-28,BDE47,BDE-100,BDE-99,BDE-154,BDE-153 and BDE-183)were measured by gas chromatography-negative chemical ionization-mass spectrometry and the influencing factors were analyzed.Results The median of total PBDEs concentration in breast milk was 8.81 ng/g lipid weight(1w),and the range was 1.92-41.55,,g/g 1W. The detection rates of seven congeners(BDE-28,BDE-47,BDE-100,BDE-99,BDE-154,BDE-153,BDE-183)were 98%(47/48),96%(46/48),86%(41/48),90%(43/48),83%(40/48),98%(47/48),90%(43/48),and the median of them was,0.88,0.99,0.97,1.39,1.14,2.17,1.41 ng/g 1w,respectively.LogΣ7PBDEs in breast milk from mothers with different education levels were divided into junior high school or lower(0.89 ±0.24),senior high school(1.02±0.17),junior college or higher(1.08±0.28).LogΣ7PBDEs in breast milk from mothers with different income levels were divided as ＜1000 yuan(0.89±0.12),1000-3000 yuan(1.01±0.24),＞3000 yuan(1.13±0.21).Correlation analysis showed that both the mothers'education level(r=0.322.P＜0.05)and income level(r=0.388.P＜0.05)have a positive correlation to PBDEs levels in breast milk. Conclusion It is very common to detect PBDEs in human breast-milk.however,the education and income levels of the mothers my be the influencing factors.