宫颈癌患者癌组织中Th17/Tr细胞明显升高与疾病进程相关

目的 了解宫颈癌患者外周血、肿瘤组织中Th17/Tr细胞的比例,分析其与疾病发生、发展的关系,探讨Th17/Tr比值改变在宫颈癌临床检测中的意义.方法 采用流式细胞术检测32例宫颈癌患者外周血、肿瘤组织标本和15例健康者对照标本中的Th17、Tr细胞;采用直线相关检验方法对晚期宫颈癌组的Th17、Tr细胞进行相关性分析.结果 宫颈癌患者外周血、肿瘤组织中Th17、Tr细胞显著高于健康对照组(P<0.05),晚期宫颈癌组Th17/Tr比值低于早期组(P<0.01),晚期宫颈癌组Th17、Tr表达呈负相关.结论 宫颈癌患者Th17、Tr细胞比例明显升高,提示Th17/Tr比值与宫颈癌的发生发展可能存在着一定的关系,为官颈癌的免疫治疗提供新思路.

Abstract：

Objective To detect the levels of Th17 and regulatory T(Tr)cells in Imripheral blood mononuclear and tumor tissue from patients with cervical cancer and analyze the relationship hetween Th17 and Tr cells in cervical cancer progression.In addition.the significance of the Th17/Tr cells ratio in cervical cancer pathogenesis was discussed.Methods The expression levels of Th17 and Tr cells were determined by flow cytometry from 32 patients with cervical cancer and 15 health people.The mechanism of involvement of Th17 and Tr cells proportionality in cervical cancer pathogenesis and the correlation between Th17 and Trwas assessed by bivariate correlation analysis.Results The expression levels of both Th17 and Tr in patients were higher than control groups,especially in late stage patients Th17 and Tr proportionality lower than early group,and there was a negative correlation between them.Conclusion Th17 and Tr cells proportionality may be involve in the development of cervical cancer so as to provide novel strategies for tumor immunotherapy.

Unbalance and involvement of Th17/Tr cells in patients with cervical cancer

Objective To detect the levels of Th17 and regulatory T(Tr)cells in Imripheral blood mononuclear and tumor tissue from patients with cervical cancer and analyze the relationship hetween Th17 and Tr cells in cervical cancer progression.In addition.the significance of the Th17/Tr cells ratio in cervical cancer pathogenesis was discussed.Methods The expression levels of Th17 and Tr cells were determined by flow cytometry from 32 patients with cervical cancer and 15 health people.The mechanism of involvement of Th17 and Tr cells proportionality in cervical cancer pathogenesis and the correlation between Th17 and Trwas assessed by bivariate correlation analysis.Results The expression levels of both Th17 and Tr in patients were higher than control groups,especially in late stage patients Th17 and Tr proportionality lower than early group,and there was a negative correlation between them.Conclusion Th17 and Tr cells proportionality may be involve in the development of cervical cancer so as to provide novel strategies for tumor immunotherapy.