帕金森病患者的记忆障碍及相关因素研究

目的研究帕金森病患者记忆障碍的特点及影响因素。方法155 例帕金森病患者分为4 个年龄组，进行临床记忆量表测评及汉密尔顿抑郁、焦虑量表测评。结果帕金森病患者记忆商明显低于全国常模(P<0.01)；帕金森病患者各年龄组联想学习、指向记忆、图像自由回忆及人像特点联系回忆得分均明显低于常模(P<0.01)，而无意义图形再认仅在帕金森患者50 岁组得分高于常模(P<0.05)；帕金森病患者的记忆商与文化程度及抑郁或焦虑情绪明显相关(P<0.01)，而与年龄、性别、病程不相关(P>0.05)。结论帕金森病患者记忆商明显较低，尤其是联想学习、指向记忆、图像自由回忆及人像特点联系方面；帕金森病患者记忆商与文化程度及抑郁焦虑情绪明显相关。

Memory Impairment and Its Related Factors in Patients with Parkinson's Disease

Objective To study the characteristic of memory impairment and its related factors in patients with Parkinson’s disease(PD).Methods 155 PD patients were assigned to 4 age groups.Clinical memory scale,Hamilton Rating Scale for Depression(HAMD) and Hamilton Rating Scale for Anxiety(HAMA) were used to assess them.Results The memory quotient(MQ) of PD patients were significantly lower than the norm(P<0.01).The scores of associational learning,direct memory,picture recall and portrait association in each age groups were lower than norm(P<0.05),but nonsense figure recognition(P>0.05).The MQ of PD patients was significantly related with education and depression or anxiety(P<0.01),and was not correlated with age,gender and course of disease(P>0.05).Conclusion The MQ of PD patients are lower especially in associational learning,direct memory,picture recall and portrait association.The MQ of PD patients is correlated with education and depression or anxiety significantly.