急性颅脑损伤患者血清NO、NOS和CNP测定的临床意义 |
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引用本文: | 姚加平,陈德忠,齐华国,刘丽. 急性颅脑损伤患者血清NO、NOS和CNP测定的临床意义[J]. 放射免疫学杂志, 2005, 18(3): 182-183 |
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作者姓名: | 姚加平 陈德忠 齐华国 刘丽 |
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作者单位: | 江苏省灌云县人民医院,222200 |
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摘 要: | 目的:探讨了NO、NOS和血浆C-型利钠多肽(CNP)水平在急性颅脑损伤早期的病理、生理作用。方法:分别应用放免法测定血浆CNP水平,生化法测定NO、NOS水平。结果:在治疗前急性颅脑损伤患者血浆CNP水平和NO水平非常显著地低于正常人组水平(P<0.01),而NOS水平显著地高于正常人组水平(P<0.01),经治疗后一个月则与正常人组比较无显著性差异(P>0.05)。结论:观察血浆CNP、NO和NOS水平的变化对研究急性早期颅脑损伤的病理生理变化,判断疗效及预后观察是具有十分重要的临床意义。
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关 键 词: | 急性颅脑损伤 C型利钠多肽(CNP) 一氧化氮 一氧化氮合成酶 |
修稿时间: | 2005-02-25 |
Clinical Significance of Determination of Plasma C-type Natriuretic Peptide(CNP) and Serum NO, NOS Levels in Patients with Acute Brain Injury |
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Abstract: | Objective To investigate the clinical significance of changes of plasma CNP and serum NO, NOS levels in patients with acute brain injury at early stage and one month later. Methods Radioimmunoassay was used for determining plasma CNP concentration and biochemistry method for serum NO, NOS levels in 30 controls and 32 patients with acute brain injury at admission and one month later. Results Before treatment plasma CNP and serum NO levels in the patients were significantly lower and serum NOS levels significantly higher than those in controls (P<0.01, P<0.01). After treatment for one month, the levels were approaching normal (P>0.05). Conclusion Plasma CNP and serum NO, NOS levels were related to the pathophysiological process of acute brain injury and might be taken as indicator of the severity of the diseases. |
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Keywords: | acute brain injury C-type natriuretic peptide(CNP) nitric oxide(NO) nitric oxide syntheses(NOS) |
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