| XELOX与FOLFOX6方案一线治疗晚期结直肠癌的近期疗效及不良反应比较 |
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| 引用本文： | 罗永忠,欧阳周.XELOX与FOLFOX6方案一线治疗晚期结直肠癌的近期疗效及不良反应比较[J].现代肿瘤医学,2010,18(1). |
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| 作者姓名： | 罗永忠 欧阳周 |
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| 作者单位： | 湖南省肿瘤医院内科,湖南,长沙,410013 |
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| 摘 要： | 目的:比较卡培他滨(希罗达)联合奥沙利铂(XELOX)方案与亚叶酸钙、5-氟尿嘧啶(5-FU)联合奥沙利铂(FOLFOX6)方案一线治疗晚期转移性结、直肠癌的疗效和不良反应.方法: 将62例晚期结、直肠癌患者随机分为两组,XELOX方案组(n=31):卡培他滨(capecitabine,Xeloda)1000mg/m2,2次/d,口服,第1天至第14天;奥沙利铂(oxaliplatin)130mg/m2,静脉滴注,持续3h,第1天;21天为1周期.FOLFOX6方案组(n=31):亚叶酸钙(CF)200mg/m2,静脉滴注,第1天,5-FU前;5-FU 400mg/m2,静脉推注,第1天,2400mg/m2,静脉持续滴注46h;奥沙利铂100mg/m2,静脉滴注,持续3h,第1天;14天为1周期. 结果: XELOX组缓解率(RR)为48.4%,中位肿瘤进展时间(TTP)6.8个月;FOLFOX6组RR为51.6%,TTP为7.1个月;两组比较各项指标差异无统计学意义(P＞0.05).不良反应中XELOX组手足综合征发生率高于FOLFOX组,Ⅲ、Ⅳ度中性粒细胞减少发生率低于FOLFOX6组.结论: XELOX 方案一线治疗晚期结、直肠癌有确切疗效,不良反应能耐受,与FOLFOX6方案相当,但XELOX方案用药更为方便,安全性更好.
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| 关 键 词： | 晚期结直肠癌 卡培他滨 奥沙利铂 |
Efficacy and side effect of XELOX and FOLFOX6 as first-line chemotherapy on metastatic colorectal cancer |
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| LUO Yong-zhong,OUYANG Zhou.Efficacy and side effect of XELOX and FOLFOX6 as first-line chemotherapy on metastatic colorectal cancer[J].Journal of Modern Oncology,2010,18(1). |
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| Authors: | LUO Yong-zhong OUYANG Zhou |
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| Institution: | LUO Yong-zhong,OUYANG Zhou Department of Medical Oncology,Hunan Tumor Hospital,Changsha 410013,China. |
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| Abstract: | Objective:To compare the clinical effects and toxicities of XELOX regimen and FOLFOX6 rigimen as the first-line chemotherapy on metastatic colorectal cancer.Methods:Sixty two metastatic colorectal cancer patients were randomly assigned to two groups,XELOX and FOLFOX6 groups.In XELOX group,patients were treated with capecitabine 1000mg/m2 oral twice everyday from day 1 to day 14;oxaliplatin 130mg/m2 iv infusion for 3 hours on day 1,repeated every 3 weeks.In FOLFOX6 group,CF 200mg/m2 iv infusion d1 followed b... |
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| Keywords: | metastatic colorectal cancer capecitabine oxaliplatin |
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