Correlation between pyrazinamide activity and pncA mutations in Mycobacterium tuberculosis isolates in Taiwan |
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| Authors: | Huang Tsi-Shu Lee Susan Shin-Jung Tu Hui-Zin Huang Wen-Kuei Chen Yao-Shen Huang Chung-Kai Wann Shue-Ren Lin Hsi-Hsun Liu Yung-Ching |
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| Affiliation: | Section of Microbiology and Infectious Diseases, Kaohsiung Veterans General Hospital and Department of Medical Technology, Foo-Yin Institute of Technology, Taipei, Taiwan. |
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| Abstract: | A total of 76 clinical Mycobacterium tuberculosis isolates from Taiwan were tested for pyrazinamidase activity, pyrazinamide susceptibility, and pncA mutations. Frequency of resistance to PZA rose with increases in resistance to first-line drugs. Of 17 pyrazinamide-resistant strains, 7 (3 of which had not been previously described) possessed mutations in the pncA gene. |
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