Pretransplantation combined therapy with plasmapheresis and rituximab in a second living-related kidney transplant pediatric recipient with a very high risk for focal segmental glomerulosclerosis recurrence |
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Authors: | Chikamoto Hiroko Hattori Motoshi Kuroda Nao Kajiho Yuko Matsumura Hideki Fujii Hiroshi Ishizuka Kiyonobu Hisano Masataka Akioka Yuko Nozu Kandai Kaito Hiroshi Shimizu Maki |
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Institution: | Department of Pediatric Nephrology, Tokyo Women's Medical University, School of Medicine, Tokyo, Japan Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan Department of Pediatrics, Takamatsu Red Cross Hospital, Takamatsu, Japan. |
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Abstract: | Chikamoto H, Hattori M, Kuroda N, Kajiho Y, Matsumura H, Fujii H, Ishizuka K, Hisano M, Akioka Y, Nozu K, Kaito H, Shimizu M. Pretransplantation combined therapy with plasmapheresis and rituximab in a second living‐related kidney transplant pediatric recipient with a very high risk for focal segmental glomerulosclerosis recurrence. Pediatr Transplantation 2011. © 2011 John Wiley & Sons A/S. Abstract: Prophylactic PP can provide some protection against post‐transplantation recurrences of FSGS, but it cannot prevent recurrences in all cases. Therefore, new preventive therapies are needed. We report on a 7.9‐yr‐old girl treated with pretransplantation prophylactic combined therapy consisting of four sessions of PP and one dose of rituximab before a second living‐related KTX. The patient had a very high risk of post‐transplantation FSGS recurrence because this had occurred after the first KTX. During the 36 months since the second transplantation, she has had no evidence of proteinuria or significant infectious complications. Although our experience is too preliminary to draw any generalizable conclusions, pretransplantation combined therapy with PP and rituximab might be a possible option for the prevention of FSGS recurrence in very high‐risk recipients undergoing living‐donor KTXs. |
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Keywords: | children focal segmental glomerulosclerosis plasmapheresis post‐transplantation recurrence prophylactic therapy rituximab |
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