Diagnosis and management of type I and type V hyperlipoproteinemia |
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Authors: | Gotoda Takanari Shirai Koji Ohta Takao Kobayashi Junji Yokoyama Shinji Oikawa Shinichi Bujo Hideaki Ishibashi Shun Arai Hidenori Yamashita Shizuya Harada-Shiba Mariko Eto Masaaki Hayashi Toshio Sone Hirohito Suzuki Hiroaki Yamada Nobuhiro;Research Committee for Primary Hyperlipidemia Research on Measures against Intractable Diseases by the Ministry of Health Labour and Welfare in Japan |
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Institution: | Department of Clinical and Molecular Epidemiology, 22nd Century Medical and Research Center, University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan. gotoda-tky@umin.ac.jp |
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Abstract: | Both type I and type V hyperlipoproteinemia are characterized by severe hypertriglyceridemia due to an increase in chylomicrons. Type I hyperlipoproteinemia is caused by a decisive abnormality of the lipoprotein lipase (LPL)- apolipoprotein C-II system, whereas the cause of type V hyperlipoproteinemia is more complicated and more closely related to acquired environmental factors. Since the relationship of hypertriglyceridemia with atherosclerosis is not as clear as that of hypercholesterolemia, and since type I and V hyperlipoproteinemia are relatively rare, few guidelines for their diagnosis and treatment have been established; however, type I and V hyperlipoproteinemia are clinically important as underlying disorders of acute pancreatitis, and appropriate management is necessary to prevent or treat such complications. Against such a background, here we propose guidelines primarily concerning the diagnosis and management of type I and V hyperlipoproteinemia in Japanese. |
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