|
|||||
|
|
Decreased serum brain-derived neurotrophic factor levels in schizophrenic patients with tardive dyskinesia |
|
| Authors: | Yang Yan Qiu Sun Shilong Yu Ya Qin Li Wen Jun Zhang Xuan Xiu Mei Hong Chen Da Chun De Yang Fu Liu Haibo Li Cunbo Kosten Thomas R Zhang Xiang Yang |
| Affiliation: | a The First Hospital of Jilin University, Changchun, China b School of Public Health, Jilin University, Changchun 130021, China c Beijing HuiLongGuan Hospital, Beijing, China d Inner Mongolia Medical College, Hohhot, China e Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA |
| Abstract: | The pathogenesis of tardive dyskinesia (TD) may involve neurodegeneration and associated dysfunction of brain-derived neurotrophic factor (BDNF) for the survival and maintenance of function in neurons. We therefore compared serum BDNF levels in schizophrenic patients with (n = 129) and without TD (n = 235), and normal controls (n = 323). Assessments included the abnormal involuntary movement scale (AIMS) and the positive and negative syndrome scale (PANSS). Our results were that patients with TD had lower serum BDNF levels than those without TD and normals. Lower serum BDNF levels were correlated with greater PANSS negative subscores, but not correlated with the AIMS scores. Serum BDNF levels did not differ between patients on typical and atypical antipsychotics and were not correlated with antipsychotic doses or years of exposure. We concluded that decreased BDNF levels might be associated with TD pathophysiology and more negative symptoms of schizophrenia. |
| Keywords: | Tardive dyskinesia Brain-derived neurotrophic factor Schizophrenia Symptom |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |