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Neural mechanisms of subliminal priming for traumatic episodic memory: an ERP study |
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| Authors: | Yun Xuyan Li Wei Qiu Jiang Jou Jerwen Wei Dongtao Tu Shen Zhang Qinglin |
| Institution: | a Institute of Tissue Regeneration Engineering (ITREN), Dankook University, South Korea b Department of Nanobiomedical Science and WCU Research Center, Dankook University Graduate School, South Korea c Department of Biomaterials Science, School of Dentistry, Dankook University, South Korea |
| Abstract: | Nerve regeneration and functional recovery have been a major issue following injury of nerve tissues. Electrospun nanofibers are known to be suitable scaffolds for neural tissue engineering applications. In addition, modified substrates often provide better environments for neurite outgrowth. This study was conducted to determine if multi-walled carbon nanotubes (MWCNTs)-coated electrospun poly (l-lactic acid-co-caprolactone) (PLCL) nanofibers improved the neurite outgrowth of rat dorsal root ganglia (DRG) neurons and focal adhesion kinase (FAK) expression of PC-12 cells. To accomplish this, the DRG neurons in either uncoated PLCL scaffolds (PLCL group) or MWCNTs-coated PLCL scaffolds (PLCL/CNT group) were cultured for nine days. MWCNTs-coated PLCL scaffolds showed improved neurite outgrowth of DRG neurons. Moreover, FAK expression was up-regulated in the PLCL/CNT group when compared to the PLCL group in a non-time-dependent manner. These findings suggest that MWCNTs-coated nanofibrous scaffolds may be alternative materials for nerve regeneration and functional recovery in neural tissue engineering. |
| Keywords: | PLCL l-lactic acid-co-caprolactone)" target="_blank">poly (l-lactic acid-co-caprolactone) CNTs carbon nanotubes MWCNTs multi-walled CNTs DRG dorsal root ganglia FAK focal adhesion kinase SEM scanning electron microscopy PBS phosphate buffered saline DAPI 4&prime 6-diamidino-2-phenylindole DIV days in vitro |
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